Status: Recruiting
The Efficacy of Watch and Wait Strategy or Surgery After Neoadjuvant Immunotherapy for Locally Advanced Colorectal Cancer With dMMR/MSI-H Guided by MRD Dynamic Monitoring: A Single-center, Open-label, Prospective, Phase II Clinical Trial.
This study is a single arm, single center, phase II, prospective clinical study aimed at exploring the effectiveness and safety of watch and wait strategy guided by dynamic minimal disease residual (MRD) monitoring to achieve clinical complete response after neoadjuvant immunotherapy for locally advanced colorectal cancer with deficient mismatch repair/ microsatellite instability-high (dMMR/MSI-H).
Participants needed: 22
Trial details
Age: 18-75Biological sex: AllType: ObservationalSponsor: Yunnan Cancer HospitalUpdated: Jun 27, 2024Locations: 1
Eligibility criteria
( 1 ) Disease characteristics 1. Histologic confirmation for colorectal adenocar...
1.Immunohistochemistry of tumor biopsy specimens suggested pMMR or microsatellit...