Cognition Improvement

The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up. The population will include individuals with neurodegenerative diseases or those at the prodromal stage of cognitive impairment, as well as healthy middle-aged and older adults serving as controls. The investigators will collect their sociodemographic, dietary, lifestyle, clinical, and neuroimaging data, as well as biological samples.

The Tinker-FUN program is a cognitive flexibility intervention designed to help older adults adapt to aging and live independently. While cognitive training is an effective way to mitigate cognitive decline, current methods do not focus on cognitive flexibility, an essential aspect of managing daily activities as one ages. The intervention aims to address this gap by offering engaging tinkering activities designed for older adults. Before expanding to a larger clinical trial, the current proposal seeks to test its feasibility among community-dwelling older adults in US.