Health Trials

Congenital Malformation

2

Review clinical trials related to Congenital Malformation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Characterization and Contribution of Genome-wide DNA Methylation (DNA Methylation Episignatures) in Rare Diseases With Prenatal Onset

It is necessary to define reference DNA Methylation Episignatures from fetal DNA. The hypotheses are: * It is possible to define reference DNA Methylation Episignatures from fetal DNA extracted from amniotic fluid or frozen tissues collected during the postmortem examination * Fetal DNA Methylation Episignatures may be different to postanal DNA Methylation Episignatures defined on DNA extracted from blood

Participants needed: 63
Trial details
Age: 0-18Biological sex: AllType: ObservationalSponsor: Assistance Publique - Hôpitaux de ParisUpdated: Mar 27, 2026Locations: 1
Eligibility criteria

Fetuses with a postmortem examination as part of the etiological diagnosis of de... [+9]

Refusal of postmortem examination in case of fetal loss [+1]

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Status: Recruiting

Genomic Sequencing and Personalized Treatment for Birth Defects in Neonatal Intensive Care Units

The purpose of study is to evaluate the benefits of using the Next Generation Sequencing Technology to diagnose birth defects and genetic diseases. The results from genomic sequencing can also significantly shorten the time of examination, improve the diagnosis rate, guide the clinical treatments. So the ultimate goal is individualized or personalized therapy and promote prognosis.

Participants needed: 2,000
Trial details
Age: Up to 28Biological sex: AllType: ObservationalSponsor: Children's Hospital of Fudan UniversityUpdated: Sep 5, 2025Locations: 1
Eligibility criteria

Neonates admitted to the Neonatal Intensive Care Units in one of the study hospi... [+4]

Previously performed exome/genome sequencing on patient [+4]

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