Deep Caries

8

Review clinical trials related to Deep Caries. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious Tissue

The goal of this prospective, observational clinical cohort study is to study the effect of the preoperative condition of the tooth on the outcome of partial removal of carious tissue in mature teeth in adults. The main questions the study aims to answer are: * Do preoperative symptoms affect the outcome? * Does the depth of the carious lesion affect the outcome? One hundred participants will be recruited. Patients who meet the eligibility criteria will be asked to give their informed consent to participate in the study. Partial carious tissue removal will be performed regardless of participation in the study because selective carious tissue removal is the standard treatment of choice for a vital tooth with a deep carious lesion according to the Finnish national treatment guidelines. Participants will be asked to fill in a questionnaire regarding symptoms 7 days post-treatment. The teeth will then be followed up for 12-24 months. The null hypothesis is that there is no difference in the success between i) deep and extremely deep carious lesions and ii) initial and mild pulpitis.

Participants needed: 100
Trial details
Age: 18-50Biological sex: AllType: ObservationalSponsor: University of HelsinkiUpdated: Apr 22, 2026Locations: 1
Eligibility criteria

the patient is communicating in the Finnish or English language [+4]

general medical condition which makes the patient more susceptible to odontogeni... [+10]

Status: Recruiting

Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth

Compare the clinical performance and patient satisfaction of Egyptian MTA, Biodentine versus Calcium Hydroxide as indirect pulp capping materials in permanent teeth

Participants needed: 35
Trial details
Phase: Phase 4Age: 22-45Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Mar 18, 2026Locations: 1
Eligibility criteria

Adult patients aged 22: 45 years old. [+5]

Patients with systemic diseases. [+3]

Status: Recruiting

Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries

This trial aims to compare treatment outcomes between Pulpotomy and Pulpectomy in treating vital primary teeth diagnosed with deep caries with symptoms of irreversible pulpits

Participants needed: 40
Trial details
Phase: Phase 2Age: 4-6Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Dec 24, 2025Locations: 1
Eligibility criteria

Aged 4 to 6 years , in good general health [+3]

Physical or mental disability. [+4]

Status: Not yet recruiting

Deep Caries in Mature Teeth With Reversible Pulpitis

This clinical trial will be conducted to clinical, radiographical and histological evaluation of pulp condition with reversible pulpities after total and selective removal of primary and secondary caries (randomized clinical trial and exo-vivo study)

Participants needed: 144
Trial details
Age: 18-40Biological sex: AllType: InterventionalSponsor: Minia UniversityUpdated: Sep 26, 2025
Eligibility criteria

The patient's age from 18 years to 40 years old [+7]

Systemic medical conditions, pregnancy, alcoholic and smoker patients. 2- Teeth...

Status: Not yet recruiting

Performance of Bioactive Low Viscosity Composite in Deep Marginal Elevation Restorations

The goal of this study is to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer Shofu Flow Plus X F03 compared to nanohybrid resin composite restoration in deep subgingival proximal cavities over a period of 12 months.

Participants needed: 50
Trial details
Age: 20-50Biological sex: AllType: InterventionalSponsor: Future University in EgyptUpdated: Mar 21, 2025
Eligibility criteria

Adults patients (20-50) [+3]

Patients with known allergic or adverse reaction to the tested materials. [+6]

Status: Not yet recruiting

Evaluation of Bioactive Giomer Material Versus Nanohybrid Resin Composite in Deep Marginal Elevation

This study will be conducted to evaluate the clinical, radiographic and periodontal performance of bioactive Giomer compared to nanohybrid resin composite restoration in deep subgingival proximal cavities extending below the CEJ over a period of 24 months.

Participants needed: 50
Trial details
Age: 20-50Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Nov 27, 2024
Eligibility criteria

Young and middle aged patients (20-50) [+3]

Patients with known allergic or adverse reaction to the tested materials. [+4]

Status: Not yet recruiting

Clinical and Radiographic Evaluation of Bioceramic Putty MTA Versus MTA in Pulpotomy of Immature Permanent Molars

The present study aims to evaluate the clinical and radiographic success of bioceramics putty MTA versus MTA in the pulpotomy of immature permanent molars The main question it aims to answer is: Will the biocermaics putty MTA have higher clinical and radiographic success rates than MTA in pulpotomy of immature permanent molars?

Participants needed: 40
Trial details
Phase: Phase 3Age: 6-8Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jul 23, 2024Locations: 1
Eligibility criteria

Patients aged from 6-8 years of both sexes have immature permanent molars [+5]

Medically compromised patients who have systemic disease. [+2]

Status: Not yet recruiting

Outcome of Selective & Nonselective Caries Removal in Permanent Teeth

Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries removal (SCR) in managing deep caries, as both methods are commonly used in clinical practice. This study will be a randomized controlled trial, with participants divided into two groups: NSCR group and SCR group. Participants of deep caries lesions (reaching more than two-thirds of dentin on periapical radiographs) Both groups will undergo either NSCR or SCR, followed by Partial Pulpotomy (PP) in cases with pulp exposure. Success rates will be assessed at follow-up visits scheduled 1, 3, and 5 years radiographs will be used to assess for pulp health(vitality). The success rate of the two categories will be assessed using a scale that includes factors such as tooth vitality, caries recurrence, and clinical signs of pulpitis. The scale will be applied at follow-up visits. The trial will be conducted in post-graduate dental clinics at Guy's hospital. Deep caries in permanent teeth is a common clinical problem that can lead to pulp exposure and subsequent restorative challenges. The aim of this study is to provide evidence-based guidance for clinicians in managing deep caries lesions, as both NSCR and SCR are commonly used in clinical practice. The results of this study will help clinicians to make informed decisions when choosing the appropriate treatment approach for their patients. In conclusion, this trial aims to compare the success rate of NSCR and SCR in managing deep caries lesions in permanent teeth, as both methods are commonly used in clinical practice. The results of this study will provide valuable insights into the effectiveness of these two treatment approaches and will help clinicians to make informed decisions when choosing the appropriate treatment approaches.

Participants needed: 168
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: King's College LondonUpdated: Apr 29, 2024
Eligibility criteria

Dental patients from routine dental care at ADC (Acute Dental Care) clinics, bot... [+8]

Presence of fistulas or swelling. [+14]