Health Trials

DFNB9

3

Review clinical trials related to DFNB9. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes

The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 years of age.

Participants needed: 180
Trial details
Age: Up to 16Biological sex: AllType: ObservationalSponsor: SensorionUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Aged ≤ 16 years on the date of signed informed consent for cohort 1 and ≤ 10 yea... [+4]

Other type of deafness, such as unilateral deafness, persistent conductive deafn... [+2]

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Status: Recruiting

A Study of EH002 Gene Therapy for Otoferlin Gene Mutation-mediated Hearing Loss

The study is designed to evaluate the safety, tolerability, and preliminary efficacy of EH002 for the treatment of congenital deafness caused by mutations in the OTOF gene. Participants may receive one or two injections of the EH002 gene therapy in one or both ears.

Participants needed: 24
Trial details
Age: 6+Biological sex: AllType: InterventionalSponsor: Yilai ShuUpdated: Jul 25, 2025Locations: 2
Eligibility criteria

The participant and/or their legal guardian must provide informed consent before... [+6]

The genetic diagnosis does not indicate an OTOF mutation. [+14]

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Status: Recruiting

A Phase I/II Clinical Trial with SENS-501 in Children Suffering from Severe to Profound Hearing Loss Due to Otoferlin (OTOF) Mutations

This study intends to assess safety, tolerability, and efficacy of SENS-501 in children between the ages of 6-31 months with pre-lingual hearing loss due to a mutation in the Otoferlin gene.

Participants needed: 12
Trial details
Phase: Phase 1, Phase 2Age: 6-31Biological sex: AllType: InterventionalSponsor: SensorionUpdated: Sep 26, 2024Locations: 2
Eligibility criteria

Children (male or female) ≥ 6 to ≤ 31 months at the time of inclusion [+5]

History of chronic, acute, or major disease, or unspecified reasons, that in the... [+6]

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