Dilation and Evacuation

4

Review clinical trials related to Dilation and Evacuation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Paracervical Block With Combined Ketorolac and Lidocaine for Osmotic Dilator Placement

The purpose of this study is to improve pain management for participantswho need osmotic dilators for cervical preparation the day before their second trimester abortion procedure.

Participants needed: 76
Trial details
Phase: Phase 2Age: 18+Biological sex: FemaleType: InterventionalSponsor: Rush University Medical CenterUpdated: Jun 17, 2026Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes

Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality. Tranexamic acid (TXA) is used commonly in obstetrics to prevent or manage intrapartum or postpartum hemorrhage and has been associated with decreased mortality and decreased blood loss at the time of birth. Some guidelines are recommending the use of TXA for both the prevention and management of bleeding for abortion care. However, there are currently no published studies assessing the association between TXA and bleeding outcomes for abortion procedures. This study will involve a randomized, placebo-controlled trial of pregnant patients aged 18 and older desiring dilation and evacuation (D\&E) for abortion or fetal demise at 18-24 weeks gestation. The primary aim is to determine whether prophylactic TXA has an effect on the need for additional interventions to control bleeding at the time of D\&E. The secondary aim is to determine whether prophylactic TXA has an effect on the mean quantitative procedural blood loss.

Participants needed: 276
Trial details
Phase: Phase 4Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of California, San DiegoUpdated: Jun 15, 2026Locations: 3
Eligibility criteria

Able to understand and sign informed consent [+2]

History of or current thromboembolic event (deep vein thrombosis, stroke, pulmon... [+7]

Status: Recruiting

Cervical Ripening Balloons for Same-Day Cervical Prep

The goal of this clinical trial is to learn if a cervical ripening balloon (Foley balloon) works to prepare the cervix before same-day outpatient dilation and evacuation (D\&E). The main questions it aims to answer are: * Is cervical preparation with cervical ripening balloon for same-day outpatient D\&E non-inferior to cervical preparation with osmotic dilators? * How feasible and safe is cervical preparation with cervical ripening balloon for same-day outpatient D\&E? * How acceptable is cervical preparation with cervical ripening balloon for same-day outpatient D\&E? Participants will: * Have cervical preparation with cervical ripening balloon (experimental group) or osmotic dilators (usual care group) * Complete two surveys, one about the cervical preparation and one about the D\&E procedure

Participants needed: 70
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: University of New MexicoUpdated: May 5, 2026Locations: 1
Eligibility criteria

Individuals who desire outpatient dilation and evacuation (D&E) [+6]

Medical conditions that require procedural management in the operating room [+1]

Status: Not yet recruiting

Intracervical Block During Laminaria Insertion

Whether intracervical block with lidocaine 1% is superior to sham procedure - intracervical injection of saline 0.9% - in terms of pain control.

Participants needed: 70
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Assaf-Harofeh Medical CenterUpdated: Jun 27, 2024
Eligibility criteria

Voluntary termination of pregnancy approved by a committee or missed abortion [+2]

Multiple pregnancy [+9]