Disruptive Behavior

12

Review clinical trials related to Disruptive Behavior. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Parent-Child Interaction Therapy (PCIT) for Children With Traumatic Brain Injury (TBI): A Stepped-Care Model

The purpose of this study is to understand how a stepped-care model of Parent-Child Interaction Therapy (Step-Up PCIT) addresses child behavioral problems among children between the ages of 2 and 7 with a traumatic brain injury (TBI).

Participants needed: 20
Trial details
Age: 2+Biological sex: AllType: InterventionalSponsor: University of MiamiUpdated: May 12, 2026Locations: 1
Eligibility criteria

Child is between the ages of 2 and 7 [+3]

Status: Recruiting

Feasibility and Acceptability of Internet-based Parent-child Interaction Therapy (I-PCIT) in Pediatric Cancer

This study is being done to learn whether a telehealth intervention called "Internet-Based Parent Child Interaction Therapy," or I-PCIT," can help parents improve the child's behavior if the child currently or previously went through cancer treatment. Parents who choose to be in this study will complete a survey to help researchers figure out if the parent is eligible for the larger study. If a parent is eligible for the larger study and chooses to participate, if so, the participants will be randomly assigned to either receive the I-PCIT intervention now or to be on a waitlist and begin I-PCIT in 5-6 months. The whole study consists of completing I-PCIT sessions with a clinician and completing 3-4 follow-up surveys after the initial screener survey.

Participants needed: 300
Trial details
Biological sex: AllType: InterventionalSponsor: Johns Hopkins All Children's HospitalUpdated: Apr 30, 2026Locations: 1
Eligibility criteria

Participants will be parents of 2-12 year-old children who (1) currently or prev... [+3]

Parents will be excluded if they or their child have cognitive, motor, or langua... [+2]

Participants needed: 800
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of South FloridaUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

caregiver or professional caring for child ages 0-12 years, or [+2]

Language other than English or Spanish. [+1]

Status: Recruiting

Empowering Youth With School Discipline Referrals as Peer Coaches

The study will examine the effects of Peer Coach Training (PCT), a strengths-based behavioral intervention for discipline-referred middle-school youth who might benefit when trained to act as change agents for their peers. Successful completion of this study will provide support for implementing PCT in school communities to empower youth in prosocial peer engagement.

Participants needed: 150
Trial details
Age: 10-15Biological sex: AllType: InterventionalSponsor: University of Southern CaliforniaUpdated: Apr 13, 2026Locations: 1
Eligibility criteria

Youth who have received at least one disciplinary referral between the first day...

Youth who have not received any disciplinary referrals between the first day of...

Status: Recruiting

Tele-PCIT for Healthy Relationships in Families At-Risk

The study will examine Parent Child Interaction Therapy (PCIT) delivered via telehealth (Tele-PCIT) for young children at risk for adverse childhood experiences and/or trauma exposure.

Participants needed: 50
Trial details
Age: 2-7Biological sex: AllType: InterventionalSponsor: Medical University of South CarolinaUpdated: Mar 6, 2026Locations: 1
Eligibility criteria

Be between 2:0-6:11 years old [+7]

None

Status: Recruiting

Step-by-Step: Evaluation of a Stepped Care Model

The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems. The stepped model consists of a brief internet-based parenting support program (Step 1). For those with continued need of additional interventions, Step 2 includes access to one of following interventions: b) a Cognitive Behavior Therapy (CBT) -Virtual Reality (VR)-assisted parenting support program, b) a Cognitive Behavior Therapy -Virtual Reality-assisted child intervention, or c) standard interventions/support at the family's unit/clinic and continued access to the study's internet-based parenting support program, after which the family may choose CBT-VR for the child or the parent.

Participants needed: 210
Trial details
Age: 8-16Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Mar 6, 2026Locations: 1
Eligibility criteria

Families with children aged 8-16 years who have difficulty controlling anger or... [+2]

Families with children younger than 8 years old or who have already turned 17, o... [+3]

Status: Not yet recruiting

Personalizing Mental Health Treatment for Youth and Families

Incompatibility between evidence-based treatments (EBTs) and the cultural values, practices, and minoritized experiences of Latine youth and families contributes to racial-ethnic disparities in mental health treatment engagement and consequently mental health outcomes. The proposed study aims to develop and pilot a novel tool - the Culturally Responsive Assessment, Formulation, and Treatment Tool (CRAFTT) - for helping clinicians decide whether, when, and how to culturally adapt EBTs for individual Latine youth clients and thereby improve the cultural compatibility of EBTs for this underserved population. Completion of this study will result in a functional decision support tool designed to improve the quality and effectiveness of mental health services for Latine youths and promote mental health equity.

Participants needed: 64
Trial details
Age: 5-15Biological sex: AllType: InterventionalSponsor: University of OregonUpdated: Feb 20, 2026
Eligibility criteria

Identify as Latino [+3]

Status: Not yet recruiting

Effects and Implementation of a Brief Version of Parent-Child Interaction Therapy

The aim of this study is to evaluate the effects and feasibility of a shortened version of Parent-Child Interaction Therapy (PCIT), supplemented with video vignettes of parenting skills and 360-virtual reality (VR)-films for parents of children aged 2-7 years with disruptive behavior problems. The main questions the study aims to answer, using a Single-Case Experimental Design, are: 1. How feasible and acceptable is the implementation of brief PCIT-VR in Sweden? 2. What are the preliminary effects of brief PCIT-VR? 3. How do parents and clinicians experience brief PCIT-VR? Families at child and adolescent psychiatry clinics will receive up to 10 PCIT sessions. Caregivers complete quantitative assessments before, during, after treatment, and at 6-months follow-up, and are asked to participate in interviews after PCIT. Feasibility and acceptability of brief PCIT VR is evaluated, as well as effectiveness outcomes, including changes in child disruptive behavior and parenting skills. Within-group analyses will examine trends in outcome measures over time.

Participants needed: 15
Trial details
Age: 2-7Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Oct 1, 2025Locations: 2
Eligibility criteria

Child aged 2-7 years [+2]

Child or family requiring more urgent intervention [+1]

Status: Recruiting

Executive Function and Parenting in Childhood

Deficits in executive functioning (EF) disproportionately impact children living in poverty and increase risk for psychopathology, particularly disruptive behavior disorders. This randomized clinical trial seeks to determine whether childhood EF, assessed across neural and behavioral units of analysis, is an experimental therapeutic target that can be directly modified through caregiver participation in the Chicago Parent Program (CPP), if increases in EF predict reduced disruptive behavior trajectories in low-income children over a short-term follow-up period, and identify which CPP-driven parenting skill improvements are the most influential in modifying EF. This work will contribute new knowledge as to whether a cost-efficient parenting intervention, developed for and with low-income families raising young children in poverty, can modify EF, a neural behavioral mechanism implicated in risk for childhood disruptive behavior problems.

Participants needed: 180
Trial details
Age: 4+Biological sex: AllType: InterventionalSponsor: University of Illinois at ChicagoUpdated: Dec 5, 2024Locations: 1
Eligibility criteria

Children must be between the ages of 4 years old and 5 years, 11 months old [+18]

Child is not between the ages of 4-5 years old [+16]

Status: Not yet recruiting

Pilot Study of Parent Training With Role-plays in Virtual Reality for Parents of Children With Behavior Problems

The main aim of this pilot trial is to evaluate preliminary effects and feasibility of a new parent training program for parents of children aged 8-16 years with disruptive behavior (e.g., angry, aggressive or defiant behavior). The parent training program is based on cognitive behavioral therapy (CBT) and includes practicing of skills in virtual reality (VR). The main questions the project aims to answer are: * What are the preliminary effects of the CBT-VR parent training program? * What is the level of parent engagement in the CBT-VR parent training program? * What are the experiences of parents and therapists of the CBT-VR parent training program? The CBT-VR parenting program is delivered at clinics during individual sessions. Parents will answer quantitative measurements before, during, and after treatment. Within-group analyses will be conducted to examine experiences and preliminary effects of the program. Parents and clinicians are also asked to participate in a qualitative interview after the program has ended.

Participants needed: 10
Trial details
Age: 8-16Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Aug 19, 2024
Eligibility criteria

Parent of a child aged 8-16 years [+2]

Parent of a child under 8 years or over 16 years of age [+3]

Status: Not yet recruiting

Pilot Study of Cognitive Behavior Therapy With Role-plays in Virtual Reality for Children With Behavior Problems

The main aim of this small pilot trial is to evaluate preliminary effects and feasibility of the child intervention YourSkills for child disruptive behavior (e.g., enhanced anger or aggressive behavior) when evaluated in Sweden for children/youth aged 10-16 years. YourSkills is based on cognitive behavioral therapy (CBT) and includes practicing of skills in virtual reality (VR). The main questions the project aims to answer are: * What are the preliminary effects of the child/youth CBT-VR-program? * What is the level of child/youth engagement in the CBT-VR program? * What are the experiences of parents, children/youth and therapists of the program? The CBT-VR program is delivered at clinics during ten individual sessions. Parents will answer quantitative measurements before and after treatment, children will answer quantitative measurements before, during and after treatment. Within- group analyses will be conducted to examine experiences and preliminary effects of the program. Parents, children and clinicians are also asked to participate in a qualitative interview after the program has ended.

Participants needed: 10
Trial details
Age: 10-16Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Aug 19, 2024
Eligibility criteria

Child/youth aged between 10-16 years with increased levels of anger or disruptiv... [+1]

Child/youth is below 10 years or above 16 years of age [+3]

Status: Recruiting

A Randomized Controlled Trial on Brief Behavioral Parent Training

RATIONALE: The access to and uptake of evidence-based behavioral parent training for children with behavioral difficulties (i.e., oppositional, defiant, aggressive, hyperactive, impulsive, and inattentive behavior) are currently limited because of a scarcity of certified therapists and long waiting lists. These problems are in part due to the long and sometimes perceived as rigid nature of most evidence-based programs and result in few families starting behavioral parent training and high dropout rates. Brief and individually tailored parenting interventions may reduce these problems and make behavioral parent training more accessible. OBJECTIVES: This project aims to increase the effective use of parent training for children with behavioral difficulties by (1) examining short and longer-term effectiveness of a new, brief, individual, and individually-tailored parent training program with optional booster sessions to prevent relapse, compared to care as usual (CAU); (2) assessing the cost-effectiveness of the brief parent training program compared to CAU. STUDY DESIGN: In this two-arm, multi-center randomized controlled trial (RCT), parents are randomly assigned (1:1 ratio) to either (a) three sessions of brief behavioral parent training with optional booster sessions, or (b) CAU, as regularly provided by the involved mental healthcare centers. The study outcomes are measured at baseline before randomization (T0), one week after the third session for parents in the brief behavioral parent training arm and eight weeks after T0 for parents in the CAU arm (first posttreatment measurement, T1), six months after T1 (second posttreatment measurement, T2) and twelve months after T1 (third posttreatment measurement, T3). STUDY POPULATION: Parents of children who experience behavioral difficulties in the home setting and were referred to a child mental healthcare center. INTERVENTION: Parents in the intervention arm receive a short, individualized, three-session training primarily aimed at reducing children's behavioral problems. It exists of two (bi)weekly individually tailored training sessions of two hours and a third session of one hour in which the training will be evaluated, and maintenance training will be provided. After that, parents wishing to receive additional support can receive single booster sessions maximum once every four weeks and/or receive care as usual. Parents in the control arm receive care as usual for children's behavioral problems. The treatments in both arms are fully embedded in Dutch routine mental health care. MAIN STUDY PARAMETERS: The primary outcome is the severity of four individual target behavioral difficulties that parents want to address in the training. Secondary outcomes are parent-reported behavioral difficulties, parent-reported child well-being, parent-reported parenting behaviors, masked audio records of mealtime routines to measure parent and child behavior, parent-reported parenting stress, parent-reported parenting self-efficacy, parent-reported parental attitude towards their child, consumption and cost of mental health care, and health state utility values. We furthermore measure evaluations of the program by parents and therapists and explore whether parental attachment, parental psychopathology, parental reward responsivity, parent-reported child reward responsivity and punishment sensitivity moderate the intervention effects.

Participants needed: 93
Trial details
Age: 2-11Biological sex: AllType: InterventionalSponsor: AccareUpdated: Jul 31, 2024Locations: 1
Eligibility criteria

The child is aged between 2 and 12 years; [+1]

The child uses psychotropic medication (currently or in the month before the scr... [+5]