Dystonias

2

Review clinical trials related to Dystonias. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Attention and Eye Movement in Parkinson's Disease

The goal of this observational and interventional study is to understand how therapeutic deep brain stimulation (DBS) affects attention, perception and cognition in participants with Parkinson's disease (PD) and non-PD movement disorders, including essential tremor (ET) and dystonia (DT). The main questions it aims to answer are: * Does impaired control of attention and eye movement in PD alter how social cues are perceived and interpreted? * Does therapeutic DBS improve or worsen attentional and perceptual deficits for social cues in PD, ET and DT? * Can DBS be optimized to restore normal attentional control in PD while remaining an effective therapy for other aspects of the disorder. * What do parts of the brain targeted by DBS contribute to the control of attention? Using an eye tracking camera, investigators will study how participants with PD, ET and DT look at and perceive facial expressions of emotion before and after starting DBS therapy, in comparison to a group of healthy participants without ET, PD, DT or DBS. Participants with PD, ET and DT will see and rate morphed facial expressions on a computer screen in three conditions: * Before starting DBS therapy (over approximately 1 hour). * In the operating room, during the standard procedure to implant DBS electrodes, while the participant is awake (for no more than 15 minutes). * After starting DBS therapy, with brief experimental changes of DBS stimulation level and frequency (over approximately 1 hour).

Participants needed: 138
Trial details
Age: 19-90Biological sex: AllType: InterventionalSponsor: University of NebraskaUpdated: May 5, 2026Locations: 1
Eligibility criteria

Ability and willingness to provide signed informed consent for this study [+14]

Corrected visual acuity insufficient to perceptually judge face stimuli [+8]

Status: Recruiting

Neurosurgical Outcome Network

The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical conditions. Clinically, the identified predictors can also be used during preoperative assessments to provide more precise guidance to patients undergoing surgery.

Participants needed: 4,500
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo BestaUpdated: Mar 30, 2026Locations: 27
Eligibility criteria

Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and e... [+8]

For cognitive and psychological assessment: patients with psychiatric diseases i...