Early Childhood Caries (ECC)

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Review clinical trials related to Early Childhood Caries (ECC). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Midwives' Perspectives on Oral Health in Pregnancy and Early Childhood: A Cross-Sectional Online Survey

This study aims to explore how midwives in Germany perceive their professional role in the context of oral health of pregnant women and young children. A nationwide, anonymous, non-interventional online survey will be conducted to assess self-perceived role, confidence in counseling, perceived barriers, information sources, and training needs. The study is designed as an exploratory cross-sectional survey without hypothesis testing.

Participants needed: 200
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: University Medical Center GoettingenUpdated: May 7, 2026
Eligibility criteria

Practicing midwives in Germany [+2]

Age < 18 years [+3]

Status: Not yet recruiting

Efficacy of Silver Diamine Fluoride Versus Nano-Silver Fluoride in Arresting Active Dentin Caries in Primary Teeth in Young Children

Early childhood caries is a major public health problem affecting preschool children worldwide. Silver Diamine Fluoride is a well-established non-invasive treatment for arresting caries; however, it causes black discoloration of treated lesions. Nano-Silver Fluoride has been introduced as an alternative that may arrest caries without discoloration. This randomized clinical trial aims to compare the efficacy of Silver Diamine Fluoride and Nano-Silver Fluoride in arresting active dentin caries in primary teeth and to assess discoloration, post-operative pain, and parental satisfaction over a 12-month follow-up period.

Participants needed: 60
Trial details
Age: 3-5Biological sex: AllType: InterventionalSponsor: October University for Modern Sciences and ArtsUpdated: Feb 2, 2026Locations: 1
Eligibility criteria

Apparently healthy children. [+4]

Children with allergy to silver from their medical history. [+6]

Status: Recruiting

Caries Risk in Children Treated Under General Anesthesia for Early Childhood Caries

This observational, cross-sectional study aims to evaluate the current caries risk profiles of children who underwent dental treatment under general anesthesia (GA) for early childhood caries (ECC) between 2015 and 2020 at Aydın Adnan Menderes University, Faculty of Dentistry. A minimum of 44 systemically healthy children will be included. Caries risk will be assessed using the Cariogram model, incorporating clinical parameters (DMFT/dmft, Plaque Index, Gingival Index, probing depth), salivary factors (stimulated flow rate, buffer capacity), and standardized questionnaires covering diet, fluoride exposure, socioeconomic status, and dental visit history. Data will be collected in a single visit, analyzed using SPSS. The study aims to provide scientific evidence for long-term preventive strategies and oral health policies targeting high-risk pediatric populations treated under GA for ECC.

Participants needed: 44
Trial details
Age: 6-16Biological sex: AllType: ObservationalSponsor: Aydin Adnan Menderes UniversityUpdated: Jan 9, 2026Locations: 1
Eligibility criteria

Pediatric patients who underwent dental treatment under general anesthesia for e... [+2]

Individuals with medical conditions that may affect oral health, such as systemi... [+2]

Status: Recruiting

Analysis of Salivary Proteins in Young Children as an Device to Improve Caries Risk Assessment

The goal of this observational study is to learn if the composition of salivary proteins in 3-year-old children, from communities with documented varying caries risks, can be used to identify future diagnostic predictors for caries risk. The main question to answer is: • Can the host´s salivary protein profile (expression and abundance) show a correlation with the caries prevalence between the individuals in the different study cohorts? Two cohorts of children with different documented demographic characteristics in the region of Stockholm (Sweden) will be examined. Participants will be asked to provide saliva samples and undergo clinical oral examinations conducted by trained dental practitioners.

Participants needed: 100
Trial details
Age: 3-3Biological sex: AllType: ObservationalSponsor: Karolinska InstitutetUpdated: May 4, 2025Locations: 1
Eligibility criteria

3-year-old children residing in the areas served by Folktandvården Danderyd and... [+1]

children older than three years [+3]