Status: Not yet recruiting
Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment
This trial aims at testing a new intensive, personalized functional targeting, transcranial magnetic stimulation technique for elderly patients (aged ≥ 65 years) suffering from a current treatment resistant depressive episode to at least one antidepressant, and suffering from significant secondary cognitive impairment. The intervention will be based on an accelerated neuromodulation technique using intermittent theta bursts (aiTBS) guided by a personalised funcitonal target within the left dorsolateral prefrontal cortex (DLPFC), using the SAINT® technology, which was recently cleared by the FDA.
Participants needed: 186
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: Rennes University HospitalUpdated: Sep 23, 2025
Eligibility criteria
Male or female, of ages ≥ 65 years at the time of screening [+11]
Major cognitive disorder according to DSM-5 criteria. [+21]