Status: Not yet recruiting
Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic .
1. To evaluate the efficacy of a standardized multimodal Opioid Sparing (OS) protocol versus conventional opioid-based analgesia in reducing acute postoperative 2. To quantify opioid consumption reduction achievable through OS strategies 3. To assess the impact of OS on hemodynamic parameters during critical surgical phases 4. To compare recovery metrics (PONV, bowel function, ambulation) 5. To evaluate the safety profile of OS anesthesia
Participants needed: 110
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Assiut UniversityUpdated: Dec 29, 2025
Eligibility criteria
Adults aged 18 to 60 years scheduled for elective laparoscopic cholecystectomy.... [+2]
Chronic opioid use (>30 MME/day for >3 months). [+5]