Status: Recruiting
Single vs. Dual Antiplatelet Therapy in Elderly or HBR Patients Undergoing Percutaneous Intervention With DCB (PICCOLETO IV-EPIC 38)
This international, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) compared to dual antiplatelet therapy (DAPT) in elderly or high bleeding risk patients undergoing percutaneous coronary intervention (PCI) with the latest generation drug-coated balloon (DCB). The study includes patients with stable or unstable coronary syndromes and aims to assess rates of ischemic and bleeding adverse events.
Participants needed: 576
Trial details
Biological sex: AllType: InterventionalSponsor: Fondazione Ricerca e Innovazione Cardiovascolare ETSUpdated: Jan 22, 2026Locations: 1
Eligibility criteria
Age ≥ 75 years or age ≥ 18 years at high bleeding risk; [+4]
Stent implantation during index or recent (<6 months) procedure; [+24]