Status: Recruiting

Using Tumor Models to Determine Treatments

The purpose of this study is to see if using Patient Derived Organoids (PDO) to choose a drug for the treatment of pancreatic cancer individually for each patient is useful. The study will look at the number of participants who have a response to their assigned drug.

Participants needed: 25

Trial details

Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: University Health Network, TorontoUpdated: Jun 23, 2026Locations: 1

Eligibility criteria

Age 18 years or over [+14]

Patients with a prior or concurrent malignancy whose natural history or treatmen... [+14]

Status: Recruiting

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.

Participants needed: 480

Trial details

Phase: Phase 1, Phase 2Age: 18-75Biological sex: AllType: InterventionalSponsor: Avenzo Therapeutics, Inc.Updated: May 13, 2026Locations: 18

Eligibility criteria

Patient must be an adult, between 18 and 75 years of age with an Eastern Coopera... [+3]

Uncontrolled hypertension. [+6]

Epithelial Tumor

Using Tumor Models to Determine Treatments

AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)