ER Wildtype

1

Review clinical trials related to ER Wildtype. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

The goal of this research study is to compare a combination of two drugs, capecitabine and elacestrant to capecitabine alone as a treatment for advanced estrogen receptor-positive (ER+) breast cancer. This study is designed for participants with cancer that has previously stopped responding to medication in the class of therapy called CDK 4/6 inhibitors, including palbociclib, ribociclib, or abemaciclb. The names of the study drugs involved in this study are: * Elacestrant (a type of selective estrogen receptor degrader) * Capecitabine (a type of fluoropyrimidine antimetabolite)

Participants needed: 297
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Kristina A. FanucciUpdated: Jun 12, 2026Locations: 1
Eligibility criteria

Participants must have histologically confirmed estrogen receptor-positive (ER+)... [+39]

Participants who have had endocrine and/or biologic therapy < 14 days prior to e... [+11]