Health Trials

Fibrolamellar Hepatocellular Carcinoma (FLC)

2

Review clinical trials related to Fibrolamellar Hepatocellular Carcinoma (FLC). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Peptide Vaccine for Fibrolamellar Hepatocellular Carcinoma Patients and Other Tumor Entities Carrying the Driver Fusion DNAJB1-PRKACA

The aim of this clinical trial is to evaluate the immunogenicity along with safety and toxicity as well as first efficacy of a DNAJB1-PRKACA fusion transcript-based peptide vaccine (Fusion-VAC-XS15) in patients with FL-HCC or other cancer entities carrying the DNAJB1-PRKACA fusion transcript as adjuvant treatment

Participants needed: 20
Trial details
Phase: Phase 1Age: 12+Biological sex: AllType: InterventionalSponsor: University Hospital TuebingenUpdated: Feb 12, 2026Locations: 2
Eligibility criteria

Ability to understand and willingness to sign a written informed consent documen... [+20]

Pregnant or breastfeeding. [+11]

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Status: Recruiting

DNAJB1-PRKACA Fusion Kinase Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Fibrolamellar Hepatocellular Carcinoma

The primary objective of the trial is the safety and tolerability of administering a vaccine targeting the DNAJB1-PRKACA fusion kinase, in combination with nivolumab and ipilimumab in patients with unresectable or metastatic FLC and with non-FLC solid tumors and to assess the T-cell response.

Participants needed: 56
Trial details
Phase: Phase 1Age: 12+Biological sex: AllType: InterventionalSponsor: Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsUpdated: Dec 3, 2025Locations: 1
Eligibility criteria

Cohort A and B: Must have histologically confirmed FLC (fibrolamellar hepatocell... [+12]

Cohort A and C: Patients with a history of prior treatment with checkpoint inhib... [+56]

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