Status: Recruiting
Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)
To find out if adding medication can help treat or prevent lymphedema and/or fibrosis related to radiation therapy, in survivors of head and neck cancer. Researchers will compare these drugs to find the most effective therapy for preventing or limiting these side effects.
Participants needed: 250
Trial details
Phase: Phase 2Biological sex: FemaleType: InterventionalSponsor: M.D. Anderson Cancer CenterUpdated: Jan 26, 2026Locations: 1
Eligibility criteria
Prior history of head and neck cancer with no active disease. [+10]
Active liver disease (Child-Pugh class B-C), cirrhosis, nor active alcoholism. [+9]