Status: Recruiting
Examining a Novel Gastrointestinal Intervention to Negate Environmental Toxicants (ENGINE)
This randomized, placebo-controlled crossover trial will test the feasibility and acceptability of using colesevelam in male firefighters with high per- and polyfluoroalkyl substances (PFAS) exposure. This trial will also explore whether colesevelam lowers blood PFAS levels and urine environmental toxicant and mold mycotoxin levels.
Participants needed: 50
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: MaleType: InterventionalSponsor: University of California, San FranciscoUpdated: Apr 24, 2026Locations: 1
Eligibility criteria
Male firefighter, active or retired [+9]
Gastroparesis or other severe gastrointestinal motility disorders [+11]