FLT3 Internal Tandem Duplication Positive

1

Review clinical trials related to FLT3 Internal Tandem Duplication Positive. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Gilteritinib Plus VA Followed By Consolidation Chemotherapy in Newly Diagnosed FLT3-ITD+ AML

This clinical trial aims to evaluate whether molecular MRD-guided chemotherapy can effectively treat FLT3-ITD mutated AML and potentially replace allogeneic hematopoietic stem cell transplantation. It primarily seeks to answer: * What is the complete remission rate after initial induction with Gilteritinib, Venetoclax, and Azacitidine? * What are the survival rates and safety of subsequent high-dose cytarabine consolidation after two cycles of this induction therapy? As a single-arm study, outcomes will be compared against historical data from standard treatments (including transplant) to assess if the new strategy is equally or more effective. Participants will: * Undergo three cycles of high-dose cytarabine consolidation after two cycles of induction therapy, contingent upon achieving deep FLT3-ITD molecular remission. * Start Gilteritinib maintenance therapy after consolidation if FLT3-ITD remains detectable, continuing until deep molecular remission is achieved again.

Participants needed: 25
Trial details
Phase: Phase 2Age: 18-59Biological sex: AllType: InterventionalSponsor: First Affiliated Hospital of Zhejiang UniversityUpdated: Feb 4, 2026Locations: 1
Eligibility criteria

Each subject (or their legal representative) must sign an informed consent form... [+3]

Diagnosed with acute promyelocytic leukemia (APL), BCR-ABL positive acute myeloi... [+7]