Status: Recruiting
TReatment for ImmUne Mediated PathopHysiology
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study will determine if suppressing inflammatory responses with either corticosteroids or equine anti-thymocyte globulin therapy improves survival for children with this rare, life-threatening condition.
Participants needed: 163
Trial details
Phase: Phase 2Age: 1-18Biological sex: AllType: InterventionalSponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Updated: May 14, 2026Locations: 24
Eligibility criteria
Patient with liver injury of ≤ 6 weeks duration resulting in an international no... [+3]
Evidence of active infection with Hepatitis A, B, C, E or evidence of acute herp... [+23]