Geographic Atrophy Secondary to Age-related Macular Degeneration

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Review clinical trials related to Geographic Atrophy Secondary to Age-related Macular Degeneration. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)

This is a non-interventional, observational study to provide insights into the short-term progression of GA secondary to AMD in participants aged ≥55 years. This is a multi-center, non-interventional, observational study which aims to identify participants who have progressive GA to allow quantification of structural and functional parameters that characterize the progression of GA, and to investigate whether these correlate with genetic or lifestyle factors.

Participants needed: 75
Trial details
Age: 55+Biological sex: AllType: ObservationalSponsor: Complement TherapeuticsUpdated: Jul 13, 2026Locations: 13
Eligibility criteria

Participants must be aged ≥55 years, at the time of signing the informed consent... [+5]

Macular atrophy secondary to any condition other than AMD in the study eye. [+22]

Status: Recruiting

A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration

To characterize the dose response relationship of FWY003 in participants with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).

Participants needed: 272
Trial details
Phase: Phase 2Age: 50+Biological sex: AllType: InterventionalSponsor: Novartis PharmaceuticalsUpdated: Jun 26, 2026Locations: 41
Eligibility criteria

A diagnosis of GA secondary to AMD in at least one eye (study eye). If both eyes... [+4]

A history of, or current evidence of, choroidal neovascularization (exudative MN... [+4]

Status: Recruiting

A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio

A Phase 2, Randomized, Placebo-controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL-3007 in Combination with Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed with Geographic Atrophy Secondary to Age-Related Macular Degeneration

Participants needed: 240
Trial details
Phase: Phase 2Age: 60+Biological sex: AllType: InterventionalSponsor: Apellis Pharmaceuticals, Inc.Updated: Jun 24, 2026Locations: 78
Eligibility criteria

The study eye must meet all inclusion criteria. If both eyes meet the inclusion... [+16]

Uncontrolled, clinically relevant history of any gastrointestinal, renal, hepati... [+25]

Status: Recruiting

An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)

This is a clinical study to evaluate the safety, tolerability and efficacy of CTx001, administered via a single subretinal injection, for GA (secondary to AMD). Safety and efficacy will be measured at regular intervals for 2 years after which long-term safety will be assessed annually for up to 5 years.

Participants needed: 75
Trial details
Phase: Phase 1, Phase 2Age: 55+Biological sex: AllType: InterventionalSponsor: Complement TherapeuticsUpdated: Jun 22, 2026Locations: 5
Eligibility criteria

Not listed

Status: Recruiting

Phase 2 Study of ADX-038 in Participants With Geographic Atrophy

Phase 2 study is designed to assess the efficacy of ADX-038 compared with placebo in participants with GA secondary to AMD. Safety, pharmacokinetics (PK), and pharmacodynamics (PD) will also be assessed.

Participants needed: 240
Trial details
Phase: Phase 2Age: 60+Biological sex: AllType: InterventionalSponsor: ADARx Pharmaceuticals, Inc.Updated: Jun 16, 2026Locations: 27
Eligibility criteria

Clinical diagnosis of GA of the macula secondary to AMD [+3]

Has GA secondary to causes other than AMD [+9]

Status: Recruiting

A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)

This is a non-interventional, observational study to provide insights into the short-term progression of GA secondary to AMD in participants aged ≥55 years. This is a multi-center, non-interventional, observational study which aims to identify participants who have progressive GA to allow quantification of structural and functional parameters that characterize the progression of GA, and to investigate whether these correlate with genetic or lifestyle factors.

Participants needed: 75
Trial details
Age: 55+Biological sex: AllType: ObservationalSponsor: Complement TherapeuticsUpdated: Jun 8, 2026Locations: 12
Eligibility criteria

Participants must be aged ≥55 years, at the time of signing the informed consent... [+5]

Macular atrophy secondary to any condition other than AMD in the study eye. [+22]

Status: Recruiting

Safety and Clinical Applicability of Transcorneal Electrical Stimulation (TES) in Geographic Atrophy

Geographic atrophy (GA) is a progressive eye disease that causes the degeneration of the retinal cells, particularly in the macula, leading to vision loss. The goal of this pilot study is to evaluate the safety and the effectiveness of transcorneal electrical stimulation (TES) therapy with the OkuStim 2 System in patients with geographic atrophy (GA). Researchers will compare the effects of two different electrical stimuli with a placebo to see if the stimuli are safe and can slow down the progression of the disease. Participants will be randomly assigned to one of these three groups: * TES-treatment with a rectangular stimulus * TES-treatment with a repetitive ramp stimulus * Placebo (sham) treatment Participants will apply the therapy at home, once a week for 30 minutes each over a duration of 1 year.

Participants needed: 70
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Okuvision GmbHUpdated: May 7, 2026Locations: 5
Eligibility criteria

Willing and able to understand the study and provide informed consent [+6]

History or presence of certain eye conditions (e.g. macular edema, abnormal bloo... [+9]

Status: Recruiting

Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration

The goal of this clinical trial is to characterize the safety and effectiveness of the i-Lumen AMD transpalpebral microcurrent device and therapy in patients with intermediate to advanced nonexudative AMD. Participants will: * Undergo an initial loading regimen, followed by 7 maintenance over the course of 11 months. * Participants will return monthly through Month 14 (3 months post-last treatment) for evaluation and monitoring.

Participants needed: 100
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: i-Lumen Scientific AUS PTY LTDUpdated: May 4, 2026Locations: 13
Eligibility criteria

Presence of at least one large druse >125 microns in diameter due to AMD. [+1]

Any implanted electrical device(s) including deep brain stimulator, hearing or v... [+17]

Status: Recruiting

A Study to Evaluate KRIYA-825 (VV-14295) in Adults With Geographic Atrophy Secondary to Age-related Macular Degeneration

The goal of this study is to evaluate how safe and tolerable KRIYA-825 (VV-14295) is and to determine how effective it is in reducing the growth of geographic atrophy (GA) lesions in the treated eye in patients with GA secondary to age-related macular degeneration (AMD).

Participants needed: 62
Trial details
Phase: Phase 1, Phase 2Age: 55-80Biological sex: AllType: InterventionalSponsor: Kriya Therapeutics, Inc.Updated: Apr 30, 2026Locations: 3
Eligibility criteria

Participant must be between 55 to 80 years of age (inclusive), at the time of si... [+6]

Any ocular disease or condition that is not GA secondary to AMD: Macular atrophy... [+12]