Gingival Bleeding

8

Review clinical trials related to Gingival Bleeding. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Efficacy and Safety of HA35 Gel for Mild Gingival Recession and Periodontal Inflammation

This is a prospective, single-arm, open-label, pilot clinical study to evaluate the efficacy and safety of topical 10% high-concentration 35 kDa hyaluronan (HA35) gel in subjects with mild gingival recession and chronic periodontal inflammation. Eligible participants will apply the HA35 gel topically to the gingival and tooth surfaces twice daily for 42 consecutive days. The primary objectives are to assess changes in gingival recession, chronic gingival or radicular pain, gingival redness and swelling, and brushing-induced bleeding. Safety and local oral tolerability will be evaluated throughout the treatment period. This is a minimal-risk, non-pharmacological, non-invasive oral care intervention.

Participants needed: 30
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Nakhia Impex LLCUpdated: May 12, 2026
Eligibility criteria

Age 18-60 years, male or female [+4]

Severe periodontitis, tooth mobility, or alveolar bone loss [+5]

Status: Recruiting

Evaluation of a Toothpaste Containing a Gum Health Active in Participants With Gingival Problem

The primary objective of this clinical study is to evaluate the impact on gingival health when participants switch to a fluoride toothpaste without gum-health actives for 4 weeks after using a proven gum-health toothpaste for 13 weeks.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Unilever R&DUpdated: Apr 30, 2026Locations: 1
Eligibility criteria

Participants need to be competent i.e., able to understand what is to take place... [+4]

Be pregnant or breastfeeding. [+15]

Status: Recruiting

Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolerance in People With Gingivitis

This study is a six-week, double-blind, randomized, parallel-group controlled clinical study. The objective of this study is to evaluate the changes to the oral microbiome, inflammatory mediators, gingival health indices and to assess oral tolerance after 4 weeks of twice daily use of differing oral hygiene regimens including mouthwash compared to a control group. A follow-up assessment will be completed 2 weeks after cessation of treatments.

Participants needed: 250
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Kenvue Brands LLCUpdated: Mar 30, 2026Locations: 1
Eligibility criteria

Significant oral soft tissue pathology or active dental caries, based on the den... [+24]

Status: Recruiting

The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes

The goal of this clinical trial is to to evaluate the antiplaque and antigingivitis effect of pure green tea mouthwash compared to placebo and essential oils mouthwashes in healthy patients. The main questions it aims to answer are: * Does pure green tea mouthwash effectively reduce dental plaque? * Does pure green tea mouthwash reduce gingival inflammation? Researchers will compare pure green tea mouthwash to Listerine Total Care, Listerine Green Tea, and placebo to see if there is a difference in plaque accumulation and gum inflammation reduction. Participants will be prohibited from using any sort of oral hygiene parctice for the whole study period (3 weeks). Instead, they will rinse with 10 ml of their assigned mouthwash twice daily for 30 seconds. Plaque index, gingival index, and staining index will be examined at multiple intervals and participants will rate their sense of oral freshness and good breath.

Participants needed: 44
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: King Abdullah University HospitalUpdated: Jan 23, 2026Locations: 1
Eligibility criteria

Non-smokers [+3]

Smokers. [+7]

Status: Recruiting

Comparison of Effectiveness of Gingival Displacement Using Retraction Cord and Aluminum Chloride Gel

This study aims to compare the horizontal gingival displacement by using a retraction cord and aluminum chloride gel, and also to determine the time taken for placement and hemorrhage after the procedure by using a retraction cord and aluminum chloride gel. Patients of both genders, age ranges from 18 to 50 years, will be selecting requiring fixed prosthesis with of minimum two abutments. This study divided in two parallel groups of 33 patients in each group.

Participants needed: 66
Trial details
Phase: Phase 4Age: 18-50Biological sex: AllType: InterventionalSponsor: Dow University of Health SciencesUpdated: Dec 1, 2025Locations: 1
Eligibility criteria

age ranges from 18 to 50 years a fixed prosthesis with minimum of two abutments. [+3]

1. Sub-gingival or supra-gingival margins 2 Periapical pathosis 3. inadequate ob...

Status: Recruiting

Comparative Evaluation of SMART Hall Technique Vs. Conventional SS Crown in Primary Molars: a Randomized Clinical Trial

Dental caries, particularly in primary molars, significantly affects children's oral health and overall well-being. Traditional management with stainless steel crowns (SSCs) involves significant tooth reduction and advanced dental skills. Introduced in the 1970s, the Hall technique offers a less invasive alternative, minimizing tooth reduction compared to SSCs. The SMART Hall technique represents a further evolution, emphasizing atraumatic cavity preparation using hand instruments. It offers advantages like minimal or no tooth reduction, minimized discomfort, improved patient cooperation, shorter treatment times, and cost-effectiveness. Silver Diamine Fluoride (SDF) emerges as a promising non-invasive approach for managing dental caries in primary teeth, though it may cause temporary tooth discoloration. However, comparative evaluation with traditional SSC restorations remains limited. To address this gap, a randomized clinical trial will evaluate the treatment outcomes of the SMART Hall technique versus conventional SSC restoration for managing occluso-proximal carious lesions (ICDAS CODE 3/4/5) in primary molars of young patients. Children aged 3 to 9 years requiring restorations will be included, assessing clinical outcomes, treatment time duration, and radiographical outcomes of both techniques at specific follow-up intervals of 3 months \& 6 months. This split mouth study will explore Clinical outcomes, radiographical outcomes, treatment time duration, and patient's pain perception with the chosen treatment modality. The findings will provide insights into the effectiveness and feasibility of the SMART Hall technique compared to the traditional SSC approach, informing evidence-based decision-making in pediatric dentistry and influencing treatment recommendations for preserving the health and function of primary molars in young children.

Participants needed: 30
Trial details
Age: 3-9Biological sex: AllType: InterventionalSponsor: C K S Teja Institute Of Dental Sciences & ResearchUpdated: Mar 3, 2025Locations: 1
Eligibility criteria

Children aged 3 to 9 years old. [+4]

Presence of severe systemic medical conditions (e.g., uncontrolled diabetes, imm... [+4]

Status: Not yet recruiting

Adjunctive Oral Hygiene Aids in Reducing Oral Hygiene Parameters Among Orthodontic Patients

Adult orthodontic patients aged 18-30 were included in a randomised, singleblind clinical research using a split-mouth design at a dental clinic. Both theWaterflosser® and the Super-Floss® water flossers are manufactured by Oral-B.

Participants needed: 102
Trial details
Age: 18-35Biological sex: AllType: InterventionalSponsor: sudhir rama varmaUpdated: Jan 22, 2025Locations: 1
Eligibility criteria

Participants aged 18-35 years undergoing orthodontic treatment and [+1]

Participants not undergoing orthodontic treatment and participants undergoing or... [+2]

Status: Recruiting

Evaluation Of Nonsurgical Treatment Of Deep Periodontal Pockets (7-10mm) Using AIRFLOW® Prophylaxis Master Device With Erythritol Powder vs Conventional Instrumentation

Periodontitis is a chronic condition associated with the inflammatory destruction of the periodontal tissues ultimately leading to tooth loss. Clinically, it is identified by key features such as clinical attachment loss (CAL), bleeding upon probing (BOP), and an increase in probing pocket depth (PPD), and/or gingival recession. Periodontitis is mediated by polymicrobial dysbiosis with keystone pathogens affecting the virulence of the entire biofilm community. The removal of this biofilm and its retention factors is the ultimate goal of clinical treatment and oral measures applied. The elimination of the biofilm has traditionally been achieved with the use of either hand instruments or power driven devices. Promoting periodontal health or diminishing bacterial presence and calculus buildup on teeth can be accomplished with the same efficacy whether using manual scalers and curettes or ultrasonic scaling instruments. Both hand and ultrasonic instruments are characterized by being time- consuming and requiring technical skill, often causing patient discomfort and post-treatment pain, including hypersensitivity resulting from the loss of hard tissue when scaling the tooth surface. Ultrasonic instruments tend to leave a rougher surface behind compared to hand instruments. While effective the current techniques all have their disadvantages. The aim of this study is to evaluate changes in probing depth clinically, Bleeding on probing, Clinical attachment level, Plaque index, Calculus index, Patient pain/discomfort, Patient satisfaction, Cost effectiveness, Treatment time and Number of pockets closed after using AIRFLOW® Prophylaxis Master device with erythritol powder.

Participants needed: 46
Trial details
Age: 16-80Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Aug 9, 2024Locations: 1
Eligibility criteria

Systemically healthy patients. [+4]

Pregnant and lactation females. [+3]