Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation

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Review clinical trials related to Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 Mutation

The objective of this study is to evaluate the safety, tolerability, efficacy profile, and effect on growth and development of vorasidenib in pediatric participants aged 12 to \< 18 years old with grade 2 glioma with an IDH1 or IDH2 mutation. The study includes a screening period, a treatment period consisting of continuous 28-day cycles of treatment, a safety follow-up period and a long-term follow-up period. The long-term follow-up period will assess participants for growth, development, and long-term safety impacts for approximately 5 years after the start of treatment or until Tanner Stage V is reached (whichever is later). Participants may undergo blood tests, heart tests (electrocardiogram (ECG)), imaging (MRI, X-ray), vital sign checks, and physical exams.

Participants needed: 10
Trial details
Phase: Phase 2Age: 12-17Biological sex: AllType: InterventionalSponsor: Institut de Recherches Internationales Servier (I.R.I.S.)Updated: Dec 16, 2025
Eligibility criteria

Weigh ≥ 25 kg at Screening. [+19]

Have had any prior anticancer therapy other than surgery (biopsy, sub-total rese... [+15]