Grief

15

Review clinical trials related to Grief. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluation of Grief Therapy Approaches for Bereaved Parents

The purpose of this study is to compare three types of support programs for parents who have lost a child. The study will see how these support programs affect participants' grief and depression symptoms. The three support programs are called Meaning-Centered Grief Therapy, Supportive Counseling, and Enhanced Usual Care.

Participants needed: 415
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of MiamiUpdated: Jul 1, 2026Locations: 5
Eligibility criteria

A biological, adoptive, step-parent or legal guardian from across the United Sta... [+59]

Significant psychiatric disturbance sufficient, in the investigator/study staff'... [+19]

Status: Recruiting

ACT for Individuals With MNCD and Their Care Partners

This project aims to implement and evaluate a dyadic intervention (i.e., acceptance commitment therapy) for persons with AD/ADRD and their care partners. We hypothesize the intervention will be feasible, acceptable, and show preliminary efficacy of the dyadic interveniotns.

Participants needed: 100
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Texas Tech UniversityUpdated: May 15, 2026Locations: 1
Eligibility criteria

18+ [+7]

Currently in an intervention for reducing anxiety or depression related to their... [+3]

Status: Recruiting

Telehealth to Reduce Mental Health in Family Caregivers

The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia when provided over telehealth.

Participants needed: 60
Trial details
Age: 18-120Biological sex: AllType: InterventionalSponsor: Texas Tech UniversityUpdated: May 15, 2026Locations: 1
Eligibility criteria

Participants must be informal caregivers (e.g., spouse; child; close friend) of... [+3]

Formal caregivers (who are being paid to take care of the patient) [+1]

Status: Recruiting

Prevention of Psychological Health Problems Via Integrated Operational Support

Sub-clinical behavioral health services in the military are performed by BH technicians, who receive minimal training. Due to this, embedding more technicians in military units is unlikely to benefit service members. Giving technicians training in, and access to, evidence-based interventions (EBI) could make their work more effective. The proposed study is a training trial examining the efficacy of the full integrated operational support (IOS) toolkit (evidence-based interventions for behavioral health), relative to routine care using standard resources, as a prevention resource for active-duty airmen.

Participants needed: 5,586
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: New York UniversityUpdated: May 15, 2026Locations: 1
Eligibility criteria

Service members seeing a behavioral health (BH) technician. [+1]

Service members who are not currently seeing a BH technician. [+1]

Status: Not yet recruiting

A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death

The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible. The main question it aims to answer is: • Is a trial to evaluate access to perinatal bereavement counselling feasible? Researchers will compare the intervention group (parents who have received counselling) to the control group (parents who have not received counselling) to see if there are differences in measurements of parents' grief and psychological symptoms. * Participants allocated to the intervention and control group will receive usual bereavement care from the perinatal bereavement team at the hospital * Parents allocated to the intervention group will receive counselling * Parents will complete validated psychometric questionnaires about their levels of perinatal grief, psychological distress, depression, and quality of life * Parents in the intervention group will be asked a series of open-ended written questions about their experience of participating in the trial * Healthcare professionals who have been involved with delivery of the intervention/referrals will be interviewed about their experience of the trial.

Participants needed: 26
Trial details
Age: 16+Biological sex: AllType: InterventionalSponsor: University of ManchesterUpdated: Mar 27, 2026
Eligibility criteria

Women and partners of women who have had a late fetal loss (from 16 weeks), stil... [+1]

Less than 16 years of age [+2]

Status: Not yet recruiting

Walk With Me (WWM) for Perinatal Grief

The goal of this clinical trial is to learn if the Along With Me web-based intervention works to decrease posttraumatic stress symptoms and suicidal ideation among bereaved parents following pregnancy and early infant loss. It will also learn whether peer guides provide additional improvements on these outcomes. The main questions it aims to answer are: • Do people who receive Along With Me or Along With Me plus a Peer Guide compared to services as usual have lower posttraumatic stress symptoms and suicidal ideation than those who do not receive the intervention? Researchers will compare Along With Me and Along With Me plus a Peer Guide to services as usual (referrals made in the hospital setting) to see if Along With Me works to prevent and address posttraumatic stress symptoms and suicidal ideation. Participants will: * Receive access to a mobile app with approximately 10 therapeutic modules about how to manage grief and other symptoms. * Receive check-ins with a Peer Guide (in the Peer Guide condition only)

Participants needed: 300
Trial details
Age: 15+Biological sex: AllType: InterventionalSponsor: Oregon Research Behavioral Intervention Strategies, Inc.Updated: Mar 6, 2026Locations: 1
Eligibility criteria

Within the first month of pregnancy or early infant loss [+3]

Not pregnant or has not experienced an early infant loss [+3]

Status: Recruiting

Improving Mental Health for Care Partners of Persons With AD/ADRD

The overarching goal of this project is to evaluate if evidence-based interventions can reduce PDG, burden, and stress in informal caregivers of individuals with dementia

Participants needed: 60
Trial details
Age: 18-120Biological sex: AllType: InterventionalSponsor: Texas Tech UniversityUpdated: Feb 12, 2026Locations: 1
Eligibility criteria

Participants must be informal caregivers (e.g., spouse; child; close friend) of... [+3]

Formal caregivers (who are being paid to take care of the patient) [+1]

Status: Recruiting

Cardiovascular Effects of Grieving

Self-affirmation (SA) theory proposes that people are motivated to maintain a positive self-image of being worthy, stable, and capable. Self-affirmation (SA) manipulations have been shown to effectively increase self-worth as well as reduce cardiovascular reactivity while enhancing cardiovascular recovery in response to stress. While SA is discussed as a way to alleviate grief, its effect on cardiovascular reactivity (CVR) and recovery to grief recall has yet to be studied within laboratory settings. This study proposes an experimental design to examine how an in-lab manipulation promoting self-affirmation can improve patients' cardiovascular responses during and after a grief recall procedure. The investigators hypothesized that grief severity (a continuous variable) interacts with condition (a categorical variable with two levels, i.e., SA intervention vs. control) to predict CV reactivity and recovery as outcomes. Primary Objective 1: To investigate effects of self-affirmation intervention on cardiovascular responses among grieving participants during and after grief recall. Secondary Objective 1: To investigate the relationship of grief severity with psychological stress.

Participants needed: 140
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of South FloridaUpdated: Jan 21, 2026Locations: 1
Eligibility criteria

Individuals aged 18 and older who have experienced the death of family member an... [+1]

Status: Not yet recruiting

Individualized Grief Support With Swanson Model

This study aims to examine the effects of individualized grief support for women experiencing pregnancy loss. The research, which will be conducted at Süleyman Demirel University, is a mixed-method design and includes both phenomenological qualitative analysis and randomized controlled quantitative trials. The sample will include 48 women; those with severe depression will be excluded. Quantitative data will be analyzed using SPSS, and qualitative data will be analyzed using content analysis.

Participants needed: 48
Trial details
Age: 18-50Biological sex: FemaleType: InterventionalSponsor: Suleyman Demirel UniversityUpdated: Jan 12, 2026Locations: 1
Eligibility criteria

Aged 18 years and above, [+5]

Women who experienced pregnancy loss after infertility treatment [+4]

Status: Recruiting

Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants

The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues among Farsi/Dari-speaking youth migrants and refugees. Investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.

Participants needed: 128
Trial details
Age: 15-29Biological sex: AllType: InterventionalSponsor: Karolinska InstitutetUpdated: Dec 12, 2025Locations: 1
Eligibility criteria

Between the ages of 15 and 29. [+6]

Is suffering from a severe mental illness, such as psychosis or severe depressio... [+3]

Status: Recruiting

A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients

Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patients' value-concordant care (secondary outcomes) at T1-T4. Hypothesis 2. Qualitative data will provide insights not captured by quantitative data. Hypothesis 3. Reductions in experiential avoidance will mediate reductions in grief and Post Traumatic Stress Disorder (PTSD) symptoms, highlighting it as important to target in future implementation.

Participants needed: 172
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Weill Medical College of Cornell UniversityUpdated: Oct 29, 2025Locations: 3
Eligibility criteria

Patients who, during their hospital stay, have been admitted to the ICU and are... [+8]

Patients and surrogate decision-makers who do not meet the eligibility criteria. [+3]

Status: Recruiting

Accelerated Resolution Therapy for Early Maladaptive Grief

The purpose study is to test the effects of accelerated resolution therapy (ART) on pre-loss grief and prolonged grief disorder among older adult family caregivers (FCGs). Additionally, to better understand predictors of response to ART, and cognitive processes that occur among grieving individuals following ART.

Participants needed: 440
Trial details
Age: 60+Biological sex: AllType: InterventionalSponsor: Mayo ClinicUpdated: Sep 25, 2025Locations: 4
Eligibility criteria

Primary caregiver of immediate family member who has a life expectancy of less t... [+2]

Since becoming a family caregiver (FCG), they have engaged in another trauma bas... [+3]

Status: Recruiting

Support for Bereaved Cancer Caregivers

Friend and family caregivers of recently deceased cancer patients experience acute bereavement following the death. Post death bereavement is an intense period of mourning that includes an unfolding of the grief process and is characterized by strong emotions and demands on cognitive resources to those who have put aside their own needs to support the dying patient with cancer. This research will test the feasibility and acceptability of a nature-based healing meditation (NBHM) intervention to support cancer caregivers' during the bereavement process.

Participants needed: 70
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Michigan State UniversityUpdated: Sep 11, 2025Locations: 1
Eligibility criteria

18 years old or older; Able and willing to provide reflexology [+4]

Unwilling to perform return demonstration with 90% accuracy

Status: Not yet recruiting

Adolescent Suicide Loss Survivors Grief Intervention Group

This study will provide evidence-based recommendations for designing interventions tailored to adolescents dealing with suicide loss. By exploring how these young people experience and make meaning of their grief, the study will contribute to the development of best practices for mental health professionals and educators working with suicide loss survivors. This study will provide evidence-based recommendations for designing interventions tailored to adolescents dealing with suicide loss. By exploring how these young people experience and make meaning of their grief, the study will contribute to the development of best practices for mental health professionals and educators working with suicide loss survivors. This study will enhance scientific understanding by examining how adolescents experience grief after suicide loss and identifying which components of bereavement interventions are most effective for this age group. It will improve societal welfare by informing the development of targeted, evidence-based support programs that address the unique mental health needs of bereaved adolescents. Long-term, the findings may reduce the risk of complicated grief and suicidality, support emotional resilience, and guide best practices in schools, clinics, and community settings for supporting youth after traumatic loss.

Participants needed: 20
Trial details
Age: 13-17Biological sex: AllType: InterventionalSponsor: Nova Southeastern UniversityUpdated: Sep 3, 2025
Eligibility criteria

- Adolescents aged 13-17 years. [+2]

Adolescents who have not experienced the loss of a loved one to suicide.

Status: Recruiting

Families Left Behind

The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.

Participants needed: 340
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: RANDUpdated: Aug 21, 2025Locations: 4
Eligibility criteria

people who lost a loved one to an unintentional drug overdose death within the p... [+3]

people who need hospitalization for psychiatric symptoms or substance use disord... [+3]