Status: Recruiting

Phase I Study of Allogeneic Transforming Growth Factor-beta Receptor Type 2 Knockout CD70 CAR NK Cells in Treatment Refractory Clear Cell Renal Cell Carcinoma

Testing an investigational cancer therapy called TGFBR-2 KO CD70 CAR NK cell therapy.

Participants needed: 30

Trial details

Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: M.D. Anderson Cancer CenterUpdated: Apr 29, 2026Locations: 1

Eligibility criteria

Participants must have histologically confirmed ccRCC that is metastatic or unre... [+18]

Presence of clinically significant ongoing Grade ≥ 2 toxicity unequivocally asso... [+23]