Heart Arrest, Out-Of-Hospital

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Review clinical trials related to Heart Arrest, Out-Of-Hospital. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Increasing Law Enforcement Application of Automated External Defibrillators (AED)s for Cardiac Arrest

The goal of this study is to learn if an automated external defibrillator (AED) training adjunct video can improve law enforcement self-efficacy, the likelihood of AED application overall, and decrease disparities in women. Participants will be asked to: * complete a brief initial survey * view an AED training adjunct video * complete another survey following the video

Participants needed: 30
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Wayne State UniversityUpdated: Jun 16, 2026Locations: 1
Eligibility criteria

Law enforcement officers from agencies in the greater Portland area served by th... [+1]

none

Status: Not yet recruiting

The Effect of SPecialty cAre on Recovery From Cardiac Arrest Trial (the SPARC Trial)

This randomized clinical trial will determine if adult participants who are in the emergency department after being resuscitated from a cardiac arrest outside of the hospital benefit from care delivered at specialized centers. The main question that it will answer is whether transferring participants to a hospital with a specialized cardiac arrest service improves recovery of function after 90 days. Participants will receive all usual medical care, but some participants will be offered transfer to a regional cardiac arrest center and others will be offered care at the closest appropriate hospital. Investigators will interview participants after 90 days to assess their recovery.

Participants needed: 1,618
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of PittsburghUpdated: Feb 5, 2026Locations: 1
Eligibility criteria

Out-of-hospital cardiac arrest [+3]

Known prior advanced directives or decision to limit critical care [+4]

Status: Not yet recruiting

Naloxone for Opioid Associated Out of Hospital Cardiac Arrest

The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of Hospital Cardiac Arrest. The investigative team plan to randomize patients in OHCA to early naloxone administration vs. placebo after initial resuscitation and measure ROSC and survival. Challenges to designing NOPACA include uncertainty regarding: 1) the available pool of participants and number of EMS agencies needed to meet enrollment targets; 2) acceptability among patients, EMS and Emergency Medicine provider stakeholders, and 3) estimates of the study outcomes needed for sample size estimates. Toward obtaining the necessary information to design NOPACA, the investigators propose a pilot RCT of participants at high risk for OA-OHCA to verify a reasonable recruitment rate; treatment fidelity and acceptability; and adequate retention and measurement of outcomes at follow up. The investigators propose incorporating hypothesis testing of the feasibility outcomes to determine progression to a definitive trial.

Participants needed: 98
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: University of California, San FranciscoUpdated: Mar 10, 2025Locations: 1
Eligibility criteria

EMS plans to administer naloxone, or administration of naloxone by EMS during th... [+5]