Hepatic Impairment (Mild and Moderate, Child-Pugh Class A and B)

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Review clinical trials related to Hepatic Impairment (Mild and Moderate, Child-Pugh Class A and B). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Pharmacokinetics and Safety of MDR-001 in Mild and Moderate Hepatic Impairment

This is a Phase I, single-center, open-label, parallel-group study. A single oral dose of MDR-001, a GLP-1 receptor agonist, will be administered to participants with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment and to matched healthy controls. The study aims to evaluate the pharmacokinetics and safety of MDR-001 in these populations. Primary pharmacokinetic endpoints include AUC and Cmax; safety endpoints include adverse events, vital signs, ECG, and laboratory assessments.

Participants needed: 32
Trial details
Phase: Phase 1Age: 18-70Biological sex: AllType: InterventionalSponsor: MindRank AI LtdUpdated: Apr 24, 2026Locations: 1
Eligibility criteria

Voluntary signed informed consent before any study-related activities, and abili... [+7]

Allergic constitution, including severe drug allergy or history of drug anaphyla... [+11]