Health Trials

High-grade B-cell Lymphoma (HGBL)

2

Review clinical trials related to High-grade B-cell Lymphoma (HGBL). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Study of Safety and Efficacy of TC011 in the Relapsed/Refractory Large B Cell Non-Hodgkin Lymphoma Patients

This is a multi-center, phase I/II study to determine the safety and efficacy of TC011(CD19 Targeted CAR-T) in adult patients with relapsed or refractory large B-cell non -hodgkin lymphoma.

Participants needed: 98
Trial details
Phase: Phase 1, Phase 2Age: 19+Biological sex: AllType: InterventionalSponsor: TICAROS Co., Ltd.Updated: Mar 16, 2026Locations: 1
Eligibility criteria

≥19 years old, ECOG 0-2, life expectancy ≥12 weeks [+7]

Unresolved ≥Grade 2 toxicities from prior therapy [+12]

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Status: Not yet recruiting

Combining Loncastuximab Tesirine and Epcoritamab in Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL)

This is a phase II study designed to evaluate the toxicity and efficacy of the combination of loncastuximab tesirine and epcoritamab in patients with relapsed/refractory aggressive B-cell lymphoma. Chimeric antigen receptor (CAR)-T cell naive patients who have failed first-line therapy and patients who have received CAR-T cells as second-line therapy and experienced CAR-T failure will be eligible for inclusion.

Participants needed: 120
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Universität MünsterUpdated: Sep 29, 2025Locations: 1
Eligibility criteria

Subjects with histologically confirmed relapsed/refractory DLBCL based on pathol... [+26]

Any prior lymphoma-directed treatment, except for first-line anti-CD20-/anthracy... [+28]

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