Health Trials

HR Positive

2

Review clinical trials related to HR Positive. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Pragmatic Study to Optimize Neoadjuvant Treatment and Surgical De-escalation in HR+/HER2- Early Breast Cancer Using Oncotype DX and Abemaciclib

This is a pragmatic phase 2 study to determine the proportion of patients with ER+ (≥10%)/HER2- EBC in whom neoadjuvant chemotherapy can be replaced by NET plus abemaciclib based on the results of the ODX RS obtained in the initial diagnostic biopsy and according to the MDT decision and to evaluate the proportion of patients undergoing breast conservative surgery and/or sentinel node biopsy

Participants needed: 150
Trial details
Phase: Phase 2Age: 18-90Biological sex: FemaleType: InterventionalSponsor: Mario Negri Institute for Pharmacological ResearchUpdated: Mar 5, 2026Locations: 1
Eligibility criteria

female aged 18 years or older [+11]

presence of distant metastases (stage IV) or stage IIIC disease, [+19]

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Status: Recruiting

PRE-I-SPY Phase I/Ib Oncology Platform Program

I-SPY Phase I/Ib (I-SPY-P1) is an open-label, multisite platform study designed to evaluate single agents or combinations in a metastatic treatment setting that may be relevant for breast cancer patients with the overall goal of moving promising drug regimens into the I-SPY 2 SMART Design Trial (NCT01042379) and/or other oncology-based trials in a timely manner.

Participants needed: 124
Trial details
Phase: Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: QuantumLeap Healthcare CollaborativeUpdated: Apr 4, 2025Locations: 7
Eligibility criteria

GIC1: The participant must have ability to understand and willingness to provide... [+15]

chemotherapy or investigational agents, 3 weeks [+17]

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