Hydrogen-oxygen Gas

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Review clinical trials related to Hydrogen-oxygen Gas. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity

The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are: * Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure? * What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity? Researchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure. Participants will: * Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA * Undergo pulmonary function tests and sampling of blod and urin before and after each session * Serve as their own controls in a double-blind, randomized, crossover study design

Participants needed: 32
Trial details
Age: 20-64Biological sex: AllType: InterventionalSponsor: Blekinge Institute of TechnologyUpdated: Dec 4, 2025Locations: 2
Eligibility criteria

Military divers actively serving, aged 20-64 years [+1]

Ongoing infection or illness that may impact pulmonary function [+5]