Hypertrophic Scar

6

Review clinical trials related to Hypertrophic Scar. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring

This is a pilot, single-center, feasibility study to evaluate a new 3D printing method for ORDP design. To our knowledge, there is no technical or clinical evaluation of ORDPs, particularly in the treatment of hypertrophic scars. The aim of our study is therefore to assess the feasibility of an innovative method of designing ORDPs for the curative treatment of post-burn hypertrophic scars, using a 3D printing process, and to describe the procedures (production time and cost).

Participants needed: 25
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Centre Hospitalier Régional Metz-ThionvilleUpdated: Jun 24, 2026Locations: 1
Eligibility criteria

Adult Patients aged > 18 years old [+3]

Patients under guardianship, curatorship or safeguard of justice [+1]

Status: Recruiting

Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy

The goal of this randomized, prospective, interventional clinical trial is to evaluate the use of Brijjit® in reducing the incidence of hypertrophic scarring in individuals undergoing gender-affirming bilateral double incision mastectomies at a single-institution, single-surgeon site (Esther A. Kim, MD). Patients will serve as a self-control (one side of the chest receives intervention, the other serves as a control). Primary endpoints include scar appearance and quality. Secondary endpoints include patient perception of the scar using the Patient and Observer Scar Assessment Scale (POSAS). Participants will be taught how to apply Brijjit® at home if any units fall off before 6 weeks postop.

Participants needed: 78
Trial details
Age: 19+Biological sex: AllType: InterventionalSponsor: University of California, San FranciscoUpdated: Jun 4, 2026Locations: 1
Eligibility criteria

Age ≥ 19 [+3]

History of keloid formation [+6]

Status: Recruiting

Zinc Oxide Versus Petrolatum Following Skin Surgery

Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).

Participants needed: 30
Trial details
Phase: Early Phase 1Age: 18+Biological sex: AllType: InterventionalSponsor: Melissa Pugliano-MauroUpdated: Aug 14, 2025Locations: 1
Eligibility criteria

≥ 18 years of age [+4]

≤ 18 years [+3]

Status: Recruiting

Cost-Effectiveness of ESWT Plus Rehabilitation vs Rehabilitation Alone in Post-Burn Scars

This randomized controlled trial (RCT) will evaluate the cost-effectiveness of combining extracorporeal shock wave therapy (ESWT) with standard rehabilitation versus standard rehabilitation alone for the management of hypertrophic post-burn scars in adults. The study will assess clinical outcomes-such as pain intensity, pruritus, and scar quality-alongside economic outcomes including cost per quality-adjusted life year (QALY) gained, direct medical costs, and indirect costs (e.g., absenteeism and reduced productivity). Results will inform health policy and resource allocation decisions for advanced burn rehabilitation interventions.

Participants needed: 104
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Al Hayah University In CairoUpdated: Apr 6, 2025Locations: 1
Eligibility criteria

Not listed

Status: Recruiting

Silicone Taping for the Improvement of Abdominal Donor Site Scars

This study will look at silicone tape compared to the current no dressing standard at the investigators institution, to determine if silicone tape provides a significant improvement in post-abdominoplasty scar appearance. Silicone tape will be added to half of the abdominoplasty incision of patients undergoing abdominally-based breast reconstruction procedures two weeks after their operation. They will be followed up and assessed at specific timepoints to determine whether the silicone improves scar outcomes in these patients.

Participants needed: 32
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Nova Scotia Health AuthorityUpdated: Feb 18, 2025Locations: 1
Eligibility criteria

undergoing de novo abdominoplasty procedures as part of their breast reconstruct...

patients with a history of collagen disease, connective tissue disorders, psoria... [+6]

Status: Not yet recruiting

Pulsed High Intensity Laser Versus Extracorporeal Shockwave Therapy on Hypertrophic Scar Post Burn

The goal of this clinical trial stydy : is to compare between the effect of pulsed high intensity laser and extracorporeal shockwave therapy on hypertrophic scar on post burned patients. The main questions is it aims to answer is : * Which is more effective on hypertrophic scar post burn Extracorporeal shockwave therapy or pulsed high intensity laser therapy? * Participants will receive the treatment for 6 weeks. * Assesment will be don before and after treatment.

Participants needed: 60
Trial details
Age: 20-45Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jan 31, 2025
Eligibility criteria

The patients age will range from 20 to 45 years. [+3]

The patients who have open wound at or near treatment site. [+5]