Hypothalamic Amenorrhea, Functional

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Review clinical trials related to Hypothalamic Amenorrhea, Functional. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Health and Lifestyle Support for Functional Hypothalamic Amenorrhea

The goal of this clinical trial is to learn whether a 10-week psychoeducational health and lifestyle intervention can help women with Functional Hypothalamic Amenorrhea (FHA) restore their endocrine balance and menstrual cycles. The main questions the study aims to answer are: Does the intervention lead to the return of regular menstrual bleeding? Does it improve hormonal markers associated with FHA recovery? To answer these questions, researchers will compare the 10-week psychoeducational intervention with treatment as usual (TAU). This comparison will help determine whether the structured program leads to faster or more reliable recovery of menstrual and endocrine function than the care women typically receive today. Participants will: Take part in a 10-week psychoeducational program focusing on health behaviors important for FHA recovery (intervention group) or receive treatment as usual (comparison group) Complete questionnaires and health assessments Provide blood samples to measure hormone levels Take part in a gynecological exam to monitor ovary activity and endometrial thickness Be followed for 9 months after the program to track progress This study builds on a previous feasibility study and will help determine whether the intervention is effective and should be used more widely to support women with FHA.

Participants needed: 70
Trial details
Age: 18-42Biological sex: FemaleType: InterventionalSponsor: Karolinska InstitutetUpdated: Feb 4, 2026Locations: 1
Eligibility criteria

female [+4]

Lack of proficiency in language [+1]

Status: Recruiting

The REgistry of Very Early Estrogen and AnovuLation

The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.

Participants needed: 100,000
Trial details
Age: 18-40Biological sex: FemaleType: ObservationalSponsor: Mayo ClinicUpdated: Nov 21, 2025Locations: 2Duration: 5 Years
Eligibility criteria

Estradiol: < 50pg/mL [+14]

Parturition/lactating in the last 6-12 months [+1]

Status: Recruiting

Assessment of Nutritional Knowledge, Habits, and Eating Behavior in Athletic Women to Evaluate the Possible Impact on Their Menstrual Function

The present study aims to investigate the degree of knowledge about nutrition and dietary habits in athletic women through validated questionnaires and to evaluate a possible impact on their menstrual function, including women with a diagnosis of functional hypothalamic amenorrhea (FHA) and women who present with a different menstrual dysfunction (oligomenorrhea or polymenorrhea in absence of organic causes).

Participants needed: 102
Trial details
Age: 16-30Biological sex: FemaleType: ObservationalSponsor: Fondazione IRCCS Policlinico San Matteo di PaviaUpdated: Apr 18, 2025Locations: 1
Eligibility criteria

Female sex [+3]

Menstrual disorders of organic cause (ovarian cysts, uterine fibroids, polyps, e... [+3]