IC-MPGN

5

Review clinical trials related to IC-MPGN. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

This study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in idiopathic immune complex mediated membranoproliferative glomerulonephritis.

Participants needed: 106
Trial details
Phase: Phase 3Age: 12-60Biological sex: AllType: InterventionalSponsor: Novartis PharmaceuticalsUpdated: Jul 13, 2026Locations: 131
Eligibility criteria

Male and female patients including adults (aged at least 18 years to ≤ 60 years)... [+6]

Participants who have undergone cell or solid organ transplantation, including k... [+17]

Status: Recruiting

Chinese Adults With Kidney Disease

This is a Phase 2 study to assess the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics of ADX-038 in adults with complement-mediated kidney diseases. The study will enroll Chinese adults with IgA nephropathy, complement 3 glomerulopathy (C3G) and immune complex membranoproliferative glomerulonephritis (IC-MPGN). The study will evaluate ADX-038 administered alone (Part A) and in combination with telitacicept (Part B).

Participants needed: 30
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: ADARx Pharmaceuticals, Inc.Updated: Jun 25, 2026Locations: 10
Eligibility criteria

Mean eGFR greater than or equal to 30 mL/min/1.73m2 [+4]

Previous kidney transplant or major solid organ transplant [+6]

Status: Recruiting

Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

This Phase 2 study is designed to assess the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of ADX-038 in adults with complement-mediated kidney diseases.

Participants needed: 45
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: ADARx Pharmaceuticals, Inc.Updated: Jun 16, 2026Locations: 29
Eligibility criteria

Mean eGFR greater than or equal to 30 mL/min/1.73m2 [+4]

Hereditary or acquired complement deficiency [+7]

Status: Recruiting

Study of Efficacy and Safety of Iptacopan in Participants With IC-MPGN

This study is designed as a multicenter, randomized, double-blind, parallel group, placebo-controlled study to evaluate the efficacy and safety of iptacopan (LNP023) in idiopathic immune complex mediated membranoproliferative glomerulonephritis.

Participants needed: 106
Trial details
Phase: Phase 3Age: 12-60Biological sex: AllType: InterventionalSponsor: Novartis PharmaceuticalsUpdated: Jun 1, 2026Locations: 130
Eligibility criteria

Male and female patients including adults (aged at least 18 years to ≤ 60 years)... [+6]

Participants who have undergone cell or solid organ transplantation, including k... [+17]

Status: Not yet recruiting

A Study of SGB-9768 in Patients with Complement-mediated Kidney Diseases

This study looks at how well and safely SGB-9768 works for patients with certain kidney diseases: primary IgA nephropathy, C3 glomerulopathy, and immune complex-related membranoproliferative glomerulonephritis. It's a phase 2 trial done at several locations where both patients and doctors know what treatment is being given.

Participants needed: 38
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Suzhou Sanegene Bio Inc.Updated: Jan 22, 2025Locations: 11
Eligibility criteria

Aged ≥18 years [+6]

Kidney biopsy indicates more than 50% tubular atrophy or interstitial fibrosis. [+13]