Status: Recruiting
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC
The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is indicated. These patients are not eligible for other Children's Hospital of Philadelphia IRB approved protocols that utilize CliniMACs technology for T depletion.
Participants needed: 100
Trial details
Phase: Early Phase 1Age: Up to 30Biological sex: AllType: InterventionalSponsor: Children's Hospital of PhiladelphiaUpdated: Feb 20, 2026Locations: 1
Eligibility criteria
Patients who lack a fully HLA matched sibling and who are candidates for allogen... [+13]
Uncontrolled bacterial, viral or fungal infections [+3]