Instability; Ankle (Ligaments) (Old Injury)

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Review clinical trials related to Instability; Ankle (Ligaments) (Old Injury). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Proprioceptive Training Program Using an Uneven Terrain Treadmill for Patients With Ankle Instability

The ROCKY REHAB trial will provide a pragmatic approach to evaluate if incorporating a rocky, uneven terrain treadmill into the proprioceptive rehabilitation received during physical therapy can improve outcomes and reduce reinjury rates in patients with ankle instability.

Participants needed: 312
Trial details
Age: 18-49Biological sex: AllType: InterventionalSponsor: Henry M. Jackson Foundation for the Advancement of Military MedicineUpdated: Jul 18, 2025Locations: 2
Eligibility criteria

Aged 18-49. [+10]

Unable to walk at the point of study enrollment. [+8]

Status: Recruiting

Bipedal vs. Unipedal Exercises in Chronic Ankle Instability

Ankle sprain is a commonly encountered condition in clinical practice, constituting approximately 15-30% of all musculoskeletal injuries. Long-term studies have demonstrated that up to 73% of patients experience at least one more ankle sprain following an acute ankle sprain. Inadequate treatment of acute ankle instability can lead to chronic ankle instability (CAI) in 30-70% of cases. Treatment approaches for CAI are classified into conservative and surgical methods. Typically, conservative treatment is initially employed to address proprioceptive deficits and static impairments. Passive, unidirectional treatments such as injections, electrotherapy, and ice, which do not target muscle strength, kinetic chain, tendon capacity, and cortical control, are reported to be insufficient or ineffective in treating CAI, relying solely on symptomatic relief. Therefore, therapeutic exercises are fundamental in CAI treatment, leading to positive developments in parameters such as strength, dynamic balance, functional status, quality of life, and injury risk. Among the most commonly used exercise approaches are proprioceptive and resistive exercises. Upon reviewing the literature, it is observed that bipedal exercises have been employed from the early stages of CAI. However, due to clinical symptoms such as pain, insecurity, and fear associated with loading the affected limb, patients tend to avoid putting weight on the affected limb, resulting in the frequent use of bipedal exercises in the early phases of rehabilitation. The aim of this study is to comparatively examine the effectiveness of unipedal exercise interventions used in the early stages of rehabilitation for individuals with CAI in terms of pain, functional stability, fear avoidance, disease severity, functional performance, balance, and patient satisfaction, in comparison to bipedal exercise interventions.

Participants needed: 40
Trial details
Age: 18-50Biological sex: AllType: InterventionalSponsor: Istanbul University - CerrahpasaUpdated: Mar 24, 2025Locations: 1
Eligibility criteria

The documented unilateral ankle instability confirmed through clinical examinati... [+2]

Presence of a history of previous surgery in the lower extremity. [+9]