Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)

1

Review clinical trials related to Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Nucleoside Therapy in Patients With Telomere Biology Disorders

The goal of this clinical trial is to learn if a combination therapy of deoxycytidine (dC) plus deoxythymidine (dT) is safe in patients with telomere biology disorders. The main questions it aims to answer are: * Is the therapy safe with tolerable side effects in patients with telomere biology disorders? * Are problems with the bone marrow or blood or lungs changed after 6 months of dC+dT treatment in patients with telomere biology disorders? Participants will: * Take study drug by mouth three times daily for 24 weeks * Make approximately 2 visits to Boston Children's Hospital during the 24 weeks: once at the beginning of treatment and once at the end of treatment. * Go to a lab for a blood draw an additional 6 times during treatment. * Have 9 phone calls with a research nurse, including one 4 weeks after treatment ends. * Keep a diary to track doses of study drug that were taken or missed.

Participants needed: 36
Trial details
Phase: Phase 1Age: 1-70Biological sex: AllType: InterventionalSponsor: Suneet AgarwalUpdated: Mar 18, 2026Locations: 1
Eligibility criteria

Age ≥ 1 year and ≤ 70 years [+7]

Participants must not have very severe aplastic anemia necessitating bone marrow... [+9]