Health Trials

IPEX

2

Review clinical trials related to IPEX. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Conception of a Diagnosis, Prognosis and Therapeutic Decision Tool for Patients With Autoimmunity and Inflammation

The main objective of this study is to generate diagnosis and therapeutic-decision tools through the identification of molecular causes of PIDs with autoimmunity/inflammation and the variability in disease outcome at the transcriptional level using a combination of omics signatures (transcriptomics, epigenomics, proteomics, metagenomics, metabolomics and lipidomics).

Participants needed: 500
Trial details
Age: 1-18Biological sex: AllType: ObservationalSponsor: Institut National de la Santé Et de la Recherche Médicale, FranceUpdated: Sep 8, 2025Locations: 1
Eligibility criteria

Individuals aged<18 y/o. [+8]

Intake of antibiotics within 2 weeks prior inclusion [+5]

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Status: Recruiting

CD4^LVFOXP3 in Participants With IPEX

This first-in-human, Phase 1 clinical trial will test the feasibility of the manufacturing and the safety of the administration of CD4\^LVFOXP3 in up to 30 evaluable human participants with IPEX and evaluate the impact of the CD4\^LVFOXP3 infusion on the disease.

Participants needed: 30
Trial details
Phase: Phase 1Age: 4-35Biological sex: MaleType: InterventionalSponsor: Bacchetta, Rosa, MDUpdated: May 22, 2025Locations: 1
Eligibility criteria

Body weight greater than 8 kg, unless assessed as able to tolerate leukapheresis [+8]

Medical instability [+7]

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