Isthmocele

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Review clinical trials related to Isthmocele. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Impact of Vertical vs. Transverse Closure on Outcomes of Laparoscopic Correction of Isthmocele

Laparoscopic repair of Isthmocele aims to restore the anatomical integrity and physiological function of the lower uterine segment. * Vertical Closure: This technique involves closing the defect along the longitudinal axis of the uterus. Proponents suggest it may be more anatomically aligned with the muscle fibers of the lower uterine segment, potentially leading to stronger scar formation and reduced tension. * Transverse Closure: This technique involves closing the defect perpendicular to the long axis of the uterus. This approach is more commonly used during primary cesarean sections. Arguments for transverse closure in isthmocele repair include familiarity for surgeons and potentially less shortening of the lower uterine segment. However, the actual impact of these different closure methods on long-term outcomes such as defect recurrence, scar integrity, and fertility, remains largely unexplored in a randomized controlled trial setting.

Participants needed: 72
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: Minia UniversityUpdated: Jun 4, 2026
Eligibility criteria

Women aged 18-45 years. [+5]

Asymptomatic isthmocele. [+6]

Status: Not yet recruiting

Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous Women

This study compares two ways of closing the uterus during cesarean delivery. In one group, the decidual layer near the uterine cavity is included in the suture. In the other group, this layer is left out. The study will examine whether these two methods differ in how well the uterine scar heals 6 to 9 months after surgery. Women having an elective cesarean delivery will be randomly assigned to one of the two closure methods. Scar healing will be assessed by ultrasound after delivery. The goal is to determine whether one method is associated with better cesarean scar healing and fewer scar defects.

Participants needed: 374
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Kantonsspital BadenUpdated: Jun 1, 2026Locations: 1
Eligibility criteria

Singleton, term pregnancy [+3]

Placenta previa [+6]

Status: Recruiting

Clinical Impact of Uterine Repair During Cesarean Section with Barbed Suture on the Incidence of Isthmocele

Pregnant women, irrespective of their pregnancy risk, who undergo a cesarean section for any reason will be randomized to one of two suturing techniques: conventional suture or barbed suture for uterine repair after the cesarean section. Following surgery, these patients will be followed up for clinical outcomes, ultrasound evaluation of the uterine scar, and study of the hypoxic-inflammatory environment of the uterine cavity.

Participants needed: 364
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Hospital Clinic of BarcelonaUpdated: Mar 13, 2025Locations: 1
Eligibility criteria

Pregnant women who deliver at Hospital Clinic of Barcelona by a planned, intrapa... [+3]

Patients who end up delivering in another center. [+4]

Status: Recruiting

Frequency of Isthmocele Following Single- Vs Double-layer Uterine Closure.

The main objective of this study is to compare the frequency of isthmocele after caesarean section according to the type of hysteroraffia performed (single or double layer suture).

Participants needed: 200
Trial details
Age: 18+Biological sex: FemaleType: ObservationalSponsor: Lorenza DriulUpdated: Nov 27, 2024Locations: 1
Eligibility criteria

Patients undergoing elective or emergency/emergency caesarean section at the cen...

Age <18 years; [+3]