Health Trials

JMML

1

Review clinical trials related to JMML. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-risk JMML patients will receive trametinib, azacitidine, fludarabine, and cytarabine.

Participants needed: 58
Trial details
Phase: Phase 1, Phase 2Age: 1-21Biological sex: AllType: InterventionalSponsor: Therapeutic Advances in Childhood Leukemia ConsortiumUpdated: Apr 15, 2026Locations: 19
Eligibility criteria

Peripheral blood monocyte count ≥ 1 × 109/L* [+28]

Patients cannot have a known allergy to any of the drugs used in the study. [+8]

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