Status: Recruiting

Prescription of Letrozole for Uterine Myoma

The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as leiomyoma and uterine size.

Participants needed: 140

Trial details

Phase: Phase 4Age: 21-53Biological sex: FemaleType: InterventionalSponsor: University of California, San FranciscoUpdated: Jun 10, 2026Locations: 5

Eligibility criteria

At least 21 and less than 54 years of age (to focus on an adult, premenopausal p... [+6]

Screening pelvic imaging indicating any leiomyomata ≥10 cm in maximum diameter,... [+20]

Status: Recruiting

Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)

The investigators are evaluating the role of senescent cells in uterine fibroids.

Participants needed: 150

Trial details

Age: 18-55Biological sex: FemaleType: ObservationalSponsor: Johns Hopkins UniversityUpdated: Dec 11, 2025Locations: 1

Eligibility criteria

Subjects must be women above the age of ≥18 - ≤55 years. [+3]

Unwilling to sign the consent form or complete questionnaire. [+2]

Status: Recruiting

An Open-Label Study to Evaluate the Effect of Elix Cycle Balance & Elix Daily Harmony on Fibroid-related Symptoms

This is a 24-week, single-arm, open-label, virtual study evaluating the effects of Elix Cycle Balance and Elix Daily Harmony on uterine fibroid-related symptoms and quality of life in 42 participants. Participants will self-administer the investigational herbal supplements daily and complete validated questionnaires at scheduled timepoints to assess symptom severity and quality of life.

Participants needed: 42

Trial details

Age: 20-45Biological sex: FemaleType: InterventionalSponsor: Zenchi, Inc.Updated: Sep 12, 2025Locations: 1

Eligibility criteria

Be female. [+15]

Does not experience a regular menstrual cycle (21-35 days). [+24]

Status: Not yet recruiting

CEH-EUS for Differentiating GISTs and Leiomyomas: A Multicenter Prospective Self-Controlled Study

The investigators conduct a prospective, multicenter diagnostic trial primarily aimed at evaluating the value of contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) in differentiating gastrointestinal stromal tumors (GISTs) from leiomyomas, as well as its predictive utility in the risk stratification of GISTs.

Participants needed: 288

Trial details

Age: 18-85Biological sex: AllType: ObservationalSponsor: Huazhong University of Science and TechnologyUpdated: Aug 6, 2025Locations: 1

Eligibility criteria

Age ≥18 years and ≤ 85 years; [+6]

Age <18 years or >85 years; [+5]

Status: Recruiting

Multicenter Observational Study of Multimodal AI for Upper GI Mesenchymal Tumor Diagnosis

This study develops a multimodal AI model using endoscopic ultrasound, white-light endoscopy, and clinical information to support the diagnosis of upper GI mesenchymal tumors and the risk stratification of gastric GISTs.

Participants needed: 130

Trial details

Age: 18+Biological sex: AllType: ObservationalSponsor: Huazhong University of Science and TechnologyUpdated: Jul 31, 2025Locations: 1

Eligibility criteria

Age ≥ 18 years old [+9]

Age < 18 years old [+5]

Status: Recruiting

Effects of Simvastatin on Uterine Leiomyoma Size

The study aims to study the effect of simvastatin on the size of uterine fibroids.

Participants needed: 60

Trial details

Phase: Phase 2Age: 18-55Biological sex: FemaleType: InterventionalSponsor: Johns Hopkins UniversityUpdated: Jul 14, 2025Locations: 1

Eligibility criteria

Signed informed written consent. [+16]

Pregnancy or lactation. [+16]