Health Trials

Leptomeningeal Disease (LMD)

2

Review clinical trials related to Leptomeningeal Disease (LMD). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

CSF and Blood Plasma Liquid Biopsy in Patients With Metastatic Solid Tumours and CNS Metastases or no CNS Metastases

This is a prospective, single-centre feasibility study of CSF ctDNA conducted at the Sunnybrook Odette Cancer Centre (SOCC), Toronto, Canada, including multiple solid tumor, stratified into cohorts according to CNS disease involvement, including leptomeningeal disease (Cohort A), parenchymal brain metastases (Cohort B), and no evidence of CNS metastases (Cohort C).

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Sunnybrook Health Sciences CentreUpdated: Jun 26, 2026Locations: 1
Eligibility criteria

Patients in Cohort A will have previously untreated or progressing leptomeningea... [+6]

Inability to understand or unwillingness to provide written informed consent (la... [+1]

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Status: Recruiting

A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This study will test safety, tolerability and PK (how the drug is absorbed, distributed and eliminated) of ascending doses of AZD1390 in combination with distinct regimens of radiation therapy

Participants needed: 180
Trial details
Phase: Phase 1Age: 18-130Biological sex: AllType: InterventionalSponsor: AstraZenecaUpdated: Dec 22, 2025Locations: 12
Eligibility criteria

Provision of formalin-fixed paraffin embedded tissue sample from primary or meta... [+20]

Administration of chemotherapy or any investigational drug in the 28 days or car... [+15]

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