Leukoplakia, Oral

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Review clinical trials related to Leukoplakia, Oral. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Topical Imiquimod Treatment of Oral Dysplasia

The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous change in the mouth). The main questions it aims to answer are: 1. Does imiquimod help to make the lesions smaller and make the abnormal cell changes less severe? 2. How can we make this treatment safer and more feasible? Participants will apply topical imiquimod cream to treat the oral dysplasia and receive two follow-up biopsies after the treatment.

Participants needed: 20
Trial details
Phase: Phase 1, Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: University of Southern CaliforniaUpdated: Mar 4, 2026Locations: 1
Eligibility criteria

The patient has a biopsy-proven diagnosis of oral epithelial dysplasia. [+3]

The patient has OL, and excisional surgical removal is indicated. [+3]