Local Anesthetic Complication

1

Review clinical trials related to Local Anesthetic Complication. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Height Adjusted Versus Standardized Dose of Bupivacaine for Spinal Anesthesia

General anesthesia during pregnancy is associated with several major risks including unanticipated difficult airway, pulmonary aspiration, and specific anesthetic effects on the newborn. Thus, intrathecal anesthesia is the technique of choice for cesarean section. Nevertheless, the main side effect of intrathecal anesthesia is arterial hypotension which depend mainly on the dose of local anesthetic administered intrathecally. To date there is no guidelines nor evidences whic help the anesthetist to precisely estimate the required dose. Most often a "standardized dose" of 8 to 10 mg of bupivacaine is administered. However, some data suggest that a lower dose may be administered resulting in less frequent arterial hypotension. Nevertheless, a well designed randomized study is lacking.

Participants needed: 250
Trial details
Age: 18-45Biological sex: FemaleType: InterventionalSponsor: University Hospital, CaenUpdated: Jul 25, 2025Locations: 1
Eligibility criteria

scheduled cesarean section with intrathecal anesthesia [+2]

unscheduled or emergent cesarean section [+4]