Localised Prostate Cancer

2

Review clinical trials related to Localised Prostate Cancer. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

BeSpoke Decision Support for Patients With Newly Diagnosed Localised Prostate Cancer

The goal of this randomised clinical trial is to assess whether personalised treatment counselling can improve the decision-making experience in patients with a new diagnosis of localised prostate cancer. The main question it aims to answer is: • Does the Bespoke Decision Support tool reduce decisional conflict in those choosing between treatment options for localised prostate cancer? Researchers will compare the addition of the Bespoke Decision Support tool to standard treatment counselling versus standard counselling alone. Patient participants will: * Receive standard counselling with or without access to the Bespoke Decision Support tool (based on arm of randomisation), prior to making a treatment decision. * Answer to questionnaires regarding urinary, sexual and bowel function and decision-making outcomes before and after making a treatment decision and at 3, 6, and 12 months after initiating treatment. * Take part in a qualitative interview to discuss their decision-making experience Health Care Professional participants will: • Take part in a qualitative interview to discuss their experience in providing decision support in the trial using the Bespoke Decision Support tool.

Participants needed: 346
Trial details
Biological sex: AllType: InterventionalSponsor: University College, LondonUpdated: Jun 10, 2026
Eligibility criteria

Newly diagnosed localised prostate cancer [+5]

Unsuitable for active treatment due to very low risk prostate cancer or signific... [+7]

Status: Not yet recruiting

Microwave Intervention Under Local Anesthesia

This study aims to evaluate the feasibility of performing a focal Targeted Microwave Ablation (TMA) procedure using Koelis TMA® under local anesthesia in patient with localized prostate cancer. Eligible patients will undergo the procedure under local anesthesia instead of general anesthesia or deep sedation as part of their routine clinical care. The primary objective is to assess the feasibility of completing the procedure under local anesthesia, defined by the proportion of patients in whom the procedure is successfully completed under local anesthesia. Secondary objectives include the assessment of safety, ease of performance, patient satisfaction, and the use of analgesic medication. This study is designed as a feasibility clinical investigation conducted in a routine clinical practice setting.

Participants needed: 20
Trial details
Age: 18+Biological sex: MaleType: InterventionalSponsor: KoelisUpdated: May 19, 2026Locations: 2
Eligibility criteria

Age>18 years old [+5]

Severe illness within the last 6 months before the screening visit, including an... [+6]