Low Energy Availability

6

Review clinical trials related to Low Energy Availability. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Effects of Resistance Training on Women With Functional Hypothalamic Amenorrhea

Functional hypothalamic amenorrhea (FHA) is a condition where women lose their menstrual periods, typically due to a combination of stress and insufficient calorie intake to fuel their daily physical activity (low energy availability). Standard medical advice often requires these women to completely stop exercising to recover their energy balance and hormones. However, this "complete rest" approach can cause severe anxiety for active individuals and removes the necessary mechanical loading that keeps bones strong. This study evaluates the safety and effectiveness of an 8-week supervised resistance training (weightlifting) program as a realistic alternative treatment for active women with FHA. The researchers compare a group of women experiencing FHA to a control group of women with regular menstrual cycles. Over the 8 weeks, participants complete three moderate-intensity, full-body weightlifting sessions per week. The primary goal is to determine if women with FHA can successfully recover their menstrual cycles while continuing to lift weights. Additionally, the study monitors changes in muscle strength, jumping performance, body composition, resting heart rate, and psychological well-being. Ultimately, this study aims to provide healthcare providers and coaches with evidence-based strategies that allow female athletes to safely maintain their athletic identity and physical health during recovery.

Participants needed: 28
Trial details
Age: 18+Biological sex: FemaleType: InterventionalSponsor: Catholic University of MurciaUpdated: May 29, 2026Locations: 1
Eligibility criteria

General Profile: Active women aged 18 to 35 years. [+3]

Hormonal Status: Current use of any hormonal contraceptives. [+3]

Status: Recruiting

Preventing Athlete Under-fueling Through Nutrition.

The goal is to improve nutrition screening and support for Division III athletes. The study will use standard, low-risk nutrition screening methods, such as measuring height, weight, grip strength, and body composition, as well as having athletes complete questionnaires. Dietitians trained in sports nutrition will provide nutrition advice based on these screenings. Data will be collected at three points during the season: before the season starts, mid-season, and after the season ends. This study builds on earlier research conducted at Case Western Reserve University that showed nutrition support can improve athletes' health and performance.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Case Western Reserve UniversityUpdated: Mar 4, 2026Locations: 1
Eligibility criteria

Age range: from 18 years of age and up [+2]

Under 18 years of age [+3]

Status: Recruiting

Characteristics of Performance in Collegiate Cheerleaders and Dancers

This study aims to investigate performance differences between collegiate cheerleaders and dancers classified as normal weight obese and those classified as normal weight lean. The study will assess differences in physical performance, lifestyle behaviors, muscle quality, and nutrition-related factors between groups. Performance testing, body composition assessment, and questionnaire-based measures will be used to characterize these relationships.

Participants needed: 65
Trial details
Age: 18-30Biological sex: AllType: ObservationalSponsor: Florida State UniversityUpdated: Jan 30, 2026Locations: 1
Eligibility criteria

Must be a part of either the Florida State University dance or cheer team [+3]

Not biologically female [+3]

Status: Recruiting

Body Composition and Lifestyle Factors in ROTC

This study aims to investigates the relationships between body composition, sleep, diet, and physical fitness in ROTC cadets. Further, it aims to evaluate the accuracy of body composition screening methods and identify lifestyle factors linked to performance. Methods include body composition testing, surveys, accelerometry, and fitness score collection from cadets.

Participants needed: 45
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Florida State UniversityUpdated: Jan 16, 2026Locations: 1
Eligibility criteria

currently enrolled as a Reserve Officer Training Corps Cadets [+1]

pregnancy [+1]

Status: Recruiting

Energy Availability and Its Impact in Elite Triathletes

This study investigates how energy availability affects performance, injury risk, and training outcomes in elite triathletes. Over two competitive seasons (2026-2027), 40 elite and sub-elite triathletes will be monitored through physiological tests, blood samples, and questionnaires. The goal is to identify markers of low energy availability and understand its impact on health and athletic performance. The study is observational and does not involve experimental treatments. Participants continue their regular training and diet while undergoing periodic assessments.

Participants needed: 40
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Bispebjerg HospitalUpdated: Nov 18, 2025Locations: 1
Eligibility criteria

Age ≥18 years [+2]

Smokers [+2]

Status: Not yet recruiting

Impact of Diet-induced Change in Energy Balance on Metabolism in Endurance Athletes

Recent research has suggested that increasing levels of physical activity are associated with a reduction in the independent components that contribute to total energy expenditure (such as resting metabolic rate and non-exercise movement) - this occurs to conserve energy required for physical activity where energy provision becomes scarce. There are potential deleterious health and performance consequences of a reduced energy supply to fundamental metabolic processes, putting individuals regularly undertaking high levels of physical activity, such as endurance athletes, at risk. However, this association is largely based on observational data in only moderately active populations, and it is currently unclear what role energy balance status and biological sex has on this relationship. This research intends to address these unknowns by assessing the impact of diet-induced manipulation of energy balance (conditions of energy deficit and energy surplus) in individuals undertaking habitually high levels of physical activity on independent components of total energy expenditure (resting metabolism, exercise and non-exercise movement). Male and female athletes conducting regular moderate-to-high training volumes will undertake a randomised crossover study with a 7-day state of energy deficit and a 7-day state of energy surplus. Participants will continue to live and train as normal, but their diet will be controlled by specific food provision over the intervention periods in order to facilitate both conditions. Independent components of energy expenditure, markers of health, metabolism and performance will be measured to allow for comparison of conditions.

Participants needed: 20
Trial details
Age: 18-49Biological sex: AllType: InterventionalSponsor: University of BathUpdated: Aug 14, 2025Locations: 1
Eligibility criteria

Self-identified endurance-trained sport participants [+2]

Diagnosis of Relative Energy Deficiency in Sport (REDs) [+15]