Lower Limb Amputation Above Knee (Injury)

5

Review clinical trials related to Lower Limb Amputation Above Knee (Injury). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Prosthetic Performance Enhancement Trial

The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.

Participants needed: 35
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of Nevada, Las VegasUpdated: Jun 23, 2026Locations: 1
Eligibility criteria

lower limb amputation at ankle (Symes) level and above [+4]

leg/foot ulcer or other conditions that cause pain during weight-bearing [+4]

Status: Recruiting

Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

The goal of this study is to find out if using microprocessor-controlled prosthetic knees (MPKs), prosthetic knees with a built-in computer, improves health outcomes related to falls in adults who use above-knee prostheses. The main questions are: * Do individuals with MPKs have fewer fall-related health issues compared to those with non-microprocessor-controlled prosthetic knees (nMPKs)? * Do individuals with MPKs have increased mobility, faster walking speed, and improved quality of life compared to those with nMPKs? Participants who have recently received an nMPK as part of their regular care can join the study. Those randomized to the control group will keep using their nMPK, while those randomized to the intervention group will receive a stance-and-swing MPK or a stance-only MPK.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Hanger Institute for Clinical Research and Education, LLCUpdated: Feb 5, 2026Locations: 1
Eligibility criteria

Unilateral transfemoral or knee disarticulation limb loss. [+8]

Any health condition that would prevent safely completing trial activities. [+4]

Status: Recruiting

Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

The goal of this proposed project is to gather community-based data from the K2-level Transfemoral Amputee (TFA) population to aid in evidence-based prescription of powered prosthetic knees (i.e., choosing the right device to maximize the benefit for each patient). The investigators intend to use this trial data along with a concurrent study being conducted within the K3-K4 level population to guide the implementation of effective prescriptions towards those that can benefit most from a given device and limit prescription to those who would not see benefit in order to ensure the most judicious use of Department of Defense (DoD) and Veteran's Affairs healthcare dollars. The findings will also be shared with the research community to help drive the design of future devices by identifying what features and functions are most beneficial to which patient populations when the devices are used outside of the laboratory. In summary, more community-based data on how powered prosthetic knees compare with the current standard in TFA populations is needed to allow for improved clinical decision making and clinical outcomes.

Participants needed: 26
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Liberating Technologies, Inc.Updated: Sep 3, 2025Locations: 1
Eligibility criteria

Are at least 18 years old [+10]

Present injuries to residual limb or contralateral leg affecting functional abil... [+4]

Status: Recruiting

Assessment of the Prosthetic System Impact on Mental Workload in Above-knee Lower Limb Amputees.

New generation of lower limb prosthesis provide improved functionalities. They are usually studied in the scope of biomechanics, sometimes PROMs like quality of life. Following users feedback, it is desirable to better understand why and how mental workload is impacted by new technologies or features. This clinical investigation will try to measure a difference between different prosthetic systems, in lab and in daily life.

Participants needed: 9
Trial details
Age: 18-84Biological sex: AllType: ObservationalSponsor: Proteor GroupUpdated: Jul 9, 2025Locations: 1
Eligibility criteria

above-knee lower limb amputation [+4]

protected person [+7]

Status: Recruiting

Self-Management for Amputee Rehabilitation Using Technology.

Lower Limb Amputations (LLAs) are a substantial burden on the Canadian health services with nearly 50,000 cases reported between 2006 and 2011. To address the challenging nature of a LLA (e.g., decreased mobility, pain, depression), patients need to go through extensive rehabilitation programs. Effective self-management programs can help those with LLA to monitor their own condition and improve their quality of life. However, a lack of self-management programs, a limited healthcare budget, and a decrease in quality of services (e.g. shorter lengths of stay for inpatients and rapid movement to outpatient services) pose further challenges for patients with LLA. Self-management programs can be provided to clients through online mobile technologies (e.g., tablet) and offer accessible, low-cost, and potentially augmentative rehabilitation after discharge, in both urban and rural areas. To address these needs, an online educational and training platform for individuals with LLA called, Self-Management for Amputee Rehabilitation using Technology (SMART) was designed and developed. SMART focuses on LLA education, prosthetic limb management, and weekly support of peers. It is monitored by a trainer through a website. SMART will be evaluated in men and women with LLA aged 50 years and over, admitted to prosthetic rehabilitation throughout BC and ON. SMART has the potential to influence a client's post-LLA needs with direct (e.g., individual's health) and indirect (e.g., healthcare utilization) benefits. The purpose of this randomized controlled trial is to evaluate the effect of SMART in community dwelling older adults with unilateral, above or below, knee amputation.

Participants needed: 82
Trial details
Age: 50+Biological sex: AllType: InterventionalSponsor: University of British ColumbiaUpdated: Jul 23, 2024Locations: 1
Eligibility criteria

Has a unilateral LLA (transtibial or transfemoral) due to diabetes or vascular d... [+5]

Substantial health conditions (e.g., congestive heart failure, diagnosed dementi... [+2]