Lower Limb Amputation Below Knee (Injury)

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Review clinical trials related to Lower Limb Amputation Below Knee (Injury). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Restoration of Normative Postural Control

The objective of this proposal is to investigate the effects of training to use direct electromyographic (dEMG) control of a powered prosthetic ankle on transtibial amputees'. The aimed questions to answer: 1. whether dEMG control will improve balance and postural stability of amputees, 2. whether dEMG control will lead to more natural neuromuscular control and coordination, 3) whether dEMG control will reduce cognitive processes. Participants will go through PT guided training on using dEMG controlled prosthetic ankles and are evaluated for their capability on functional tasks. The results will be compared with a comparison group, which goes through the same training but with their everyday passive prostheses on balance capability, neuromuscular coordination, and cognitive load during locomotion.

Participants needed: 50
Trial details
Age: 18-99Biological sex: AllType: InterventionalSponsor: North Carolina State UniversityUpdated: Jul 2, 2026Locations: 1
Eligibility criteria

18 years or older; [+6]

Have a very short residual shank (the length of the residual limb is ≤15% of the... [+7]

Status: Recruiting

Prosthetic Performance Enhancement Trial

The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.

Participants needed: 35
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of Nevada, Las VegasUpdated: Jun 23, 2026Locations: 1
Eligibility criteria

lower limb amputation at ankle (Symes) level and above [+4]

leg/foot ulcer or other conditions that cause pain during weight-bearing [+4]

Status: Recruiting

An Automatically Adjusting Prosthetic Socket for People With Transtibial Amputation

People with leg amputations often experience daily changes in the size (volume) of their residual limb. These daily changes can cause a prosthesis to fit poorly. They can also cause limb problems like pain or skin breakdown. Prosthetic socket systems that accommodate limb volume changes can help address these issues, but they require users to make adjustments throughout the day. The aim of this research is to create a system that will automatically adjust the fit of the socket and create a well-fitting prosthesis for people with leg amputations who experience volume fluctuations when using their prosthesis.

Participants needed: 100
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of WashingtonUpdated: May 7, 2026Locations: 1
Eligibility criteria

18 years or older [+8]

Status: Recruiting

Caesar Foot Take-Home Validation Testing

The rationale for this study is to conduct a take-home clinical trial to evaluate the impact of the bimodal Caesar foot in a real-world environment. Participants will take the device home and use it throughout their daily life for two months. A one-month baseline period, using their usual foot, will be completed both before and after the two-month period with the Caesar foot condition. Self-report surveys and performance-based measures will be collected in the clinic at the end of each condition. The intent of this study is to determine the Caesar foot's feasibility in a real-world environment. Data will be collected to understand impact to the user's daily life and physical activity through outcomes and participant feedback. The feedback obtained during this study will be essential to informing the design intended for commercialization.

Participants needed: 18
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Liberating Technologies, Inc.Updated: Oct 14, 2025Locations: 1
Eligibility criteria

Have transtibial limb absence of one or both limbs [+9]

Present or sustained injuries to residual limb or contralateral leg affecting fu... [+2]

Status: Recruiting

R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment

Lower limb amputees (LLA) rely on their prosthetic legs to remain active and lead an independent life. For most LLAs, a well-fitted prosthetic socket is the only option to interface with their prosthetic leg, however, it is a real challenge to make a prosthetic socket to interface with residual limbs accurately. One of the reasons is that there lack of accurate approaches to evaluate the pressure distribution on the residual limb accurately and effectively. To overcome this issue, the research team will develop an innovative sensing system, which permits the prosthetists to track the pressure distribution on the residual limb visually. The capability of the new sensing system will be demonstrated on lower limb amputees.

Participants needed: 3
Trial details
Age: 18-99Biological sex: AllType: InterventionalSponsor: North Carolina State UniversityUpdated: May 20, 2025Locations: 1
Eligibility criteria

Unilateral transtibial amputees [+4]

Cognitive or visual impairment that affects the participant's ability to provide... [+2]

Status: Recruiting

Human-Prosthetic Interaction: Brain & Technology After Lower-Limb Loss

This study evaluates brain neuroplasticity and functional performance in people with unilateral lower limb amputation.

Participants needed: 60
Trial details
Age: 18-65Biological sex: AllType: InterventionalSponsor: Vrije Universiteit BrusselUpdated: Feb 24, 2025Locations: 1
Eligibility criteria

Unilateral transtibial (below knee) amputation [+2]

Any neurological disease [+4]

Status: Recruiting

Self-Management for Amputee Rehabilitation Using Technology.

Lower Limb Amputations (LLAs) are a substantial burden on the Canadian health services with nearly 50,000 cases reported between 2006 and 2011. To address the challenging nature of a LLA (e.g., decreased mobility, pain, depression), patients need to go through extensive rehabilitation programs. Effective self-management programs can help those with LLA to monitor their own condition and improve their quality of life. However, a lack of self-management programs, a limited healthcare budget, and a decrease in quality of services (e.g. shorter lengths of stay for inpatients and rapid movement to outpatient services) pose further challenges for patients with LLA. Self-management programs can be provided to clients through online mobile technologies (e.g., tablet) and offer accessible, low-cost, and potentially augmentative rehabilitation after discharge, in both urban and rural areas. To address these needs, an online educational and training platform for individuals with LLA called, Self-Management for Amputee Rehabilitation using Technology (SMART) was designed and developed. SMART focuses on LLA education, prosthetic limb management, and weekly support of peers. It is monitored by a trainer through a website. SMART will be evaluated in men and women with LLA aged 50 years and over, admitted to prosthetic rehabilitation throughout BC and ON. SMART has the potential to influence a client's post-LLA needs with direct (e.g., individual's health) and indirect (e.g., healthcare utilization) benefits. The purpose of this randomized controlled trial is to evaluate the effect of SMART in community dwelling older adults with unilateral, above or below, knee amputation.

Participants needed: 82
Trial details
Age: 50+Biological sex: AllType: InterventionalSponsor: University of British ColumbiaUpdated: Jul 23, 2024Locations: 1
Eligibility criteria

Has a unilateral LLA (transtibial or transfemoral) due to diabetes or vascular d... [+5]

Substantial health conditions (e.g., congestive heart failure, diagnosed dementi... [+2]