Medulloblastoma, Adult

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Review clinical trials related to Medulloblastoma, Adult. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

B7-H3.CD28Z.CART in CNS Neoplasms

The purpose of this research study is to test the safety and effectiveness of a cell therapy at different doses for children and young adults with recurrent or progressive brain tumors. Recurrent/recurred means a tumor that has gone away and then came back. This cell therapy is called B7- H3.CD28Z.CART, referred to as B7-H3 CAR T cells. B7-H3 is a protein that is over-expressed on many tumor cells, making it a good target for cancer cell therapy. The names of the study investigational therapies involved in this study are: * Fludarabine (a type of chemotherapy) * Cyclophosphamide (a type of chemotherapy) * B7-H3 CAR T cells (a type of cellular therapy)

Participants needed: 70
Trial details
Phase: Phase 1Age: 2-21Biological sex: AllType: InterventionalSponsor: Robbie MajznerUpdated: Feb 5, 2026Locations: 2
Eligibility criteria

Participants must have histologically and/or molecularly confirmed CNS embryonal... [+55]

Tumor with diameter of >5cm in one dimension on T2/FLAIR sequence [+18]