Health Trials

Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

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Review clinical trials related to Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

The primary objectives of this trial are to evaluate the safety profile of AMG 436 and to determine the maximum tolerated dose (MTD) and/or the recommended dose for AMG 436 as monotherapy and in combination with other anti-cancer therapies in participants with MSI-H/dMMR solid tumors.

Participants needed: 464
Trial details
Phase: Phase 1Age: 18-99Biological sex: AllType: InterventionalSponsor: AmgenUpdated: Jul 2, 2026Locations: 20
Eligibility criteria

Age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years). [+5]

Participants with primary central nervous system (CNS) tumors. [+5]

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