Status: Recruiting
CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT
The major morbidities of allogeneic hematopoietic stem cell transplant with non-human leukocyte antigen (HLA) matched siblings are graft vs host disease (GVHD) and life threatening infections. T depletion of the donor hematopoietic stem cell graft is effective in preventing GVHD, but immune reconstitution is slow, increasing the risk of infections. An addback of donor CD45RA (naive T cells) depleted cells may improve immune reconstitution and help decrease the risk of infections.
Participants needed: 50
Trial details
Age: Up to 25Biological sex: AllType: InterventionalSponsor: Children's Hospital of PhiladelphiaUpdated: Feb 20, 2026Locations: 1
Eligibility criteria
Age: Patients <25 years. [+4]
Patients who do not meet institutional disease, organ or infectious criteria [+7]