Moderate Hepatic Impairment

2

Review clinical trials related to Moderate Hepatic Impairment. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment

The purpose of this study is to measure the pharmacokinetics (PK), safety, and tolerability of capivasertib in participants with moderate hepatic impairment and participants with normal hepatic function (as control).

Participants needed: 20
Trial details
Phase: Phase 1Age: 18-80Biological sex: AllType: InterventionalSponsor: AstraZenecaUpdated: Jul 2, 2026Locations: 2
Eligibility criteria

Body weight of at least 50 kg and Body Mass Index (BMI) of between ≥ 18 up to ≤... [+7]

Any evidence of diseases (such as severe or uncontrolled systemic diseases, incl... [+14]

Status: Recruiting

Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)

The primary purpose of this study is to evaluate the plasma PK of zanzalintinib following a single dose in participants with moderate liver dysfunction compared to matched healthy participants with normal liver function.

Participants needed: 20
Trial details
Phase: Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: ExelixisUpdated: Jun 22, 2025Locations: 2
Eligibility criteria

No clinically significant medical history (aside from the HI for participants in... [+6]

• History of any medical or surgical conditions that would potentially alter abs... [+6]